Is it a teratoma? is it a nephroblastoma? no, it is a teratoma with nephroblastoma: a rare tumor in pediatric oncology

Erlyn Smith; Adriana Montilla; Chandra Krishnan

doi:10.18203/2349-3291.ijcp20233244

Authors

Erlyn Smith Department of Pediatrics, University of Florida, Ascension Sacred Heart, Pensacola, Florida
Adriana Montilla Department of Pediatrics, University of Florida, Ascension Sacred Heart, Pensacola, Florida
Chandra Krishnan Department of Pathology, University of Texas, Dell Children’s Medical Center, Austin, Texas

DOI:

https://doi.org/10.18203/2349-3291.ijcp20233244

Keywords:

Wilms tumor, Nephroblastoma, Extragonal teratoma, Teratoma with nephroblastoma, Teratoid Wilms tumor, Teratoid nephroblastoma

Abstract

Mixed extragonadal teratoma with malignant nephroblastoma (TWN) is an exceptionally rare and complex combination of solid tumors which has been referred to as “teratoid Wilms tumor,” “teratoid nephroblastoma,” or “teratoma with nephroblastoma.” Here we report a seven-year-old male who presented with a large retroperitoneal mass outside of the right kidney with lung metastases and diagnosed with a malignant mixed germ cell tumor with mature teratoma and extensive malignant nephroblastoma. Our case report highlights the controversial pathogenesis of this rare tumor and describes the variety of treatment regimens delivered for this type of tumor. In this case report, we described a young child with metastatic TWN who was successfully treated with multimodal approach based on Wilms tumor management including surgery, chemotherapy, and radiation.

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