Analyzing the complications of children with obesity: a systematic review of its effective management based on the latest guidelines
DOI:
https://doi.org/10.18203/2349-3291.ijcp20232255Keywords:
Pediatric obesity, BMI, Bariatric surgery, Lifestyle factors, InterventionAbstract
The epidemic of children with obesity has quickly become a significant issue for public health worldwide. Positive energy balance owing to calorie intake exceeding caloric expenditure and a genetic propensity for weight growth is the most prevalent cause of obesity. The goal of evaluating children with obesity is to identify the factors that led to their weight increase and any associated health problems. Children's weight control rests mainly on family-based lifestyle treatments, such as food changes and increased physical activity. A study was conducted to understand and evaluate the measures for effectively managing the complications in children with obesity. The study was carried out based on PRISMA guidelines. The systematic literature search was conducted between 2018 to 2023 from databases such as Medline/PubMed and psych info. Considering the inclusion criteria, 44 articles were included in the present review. The result showed that most of the studies included in this review were conducted on adolescents with obesity aged 5-19 years. Much of the research was a randomized cohort study that focused on the interventions for effective weight management in adolescents. Many studies also included parents and pregnant women as their study subjects. The findings of the studies involved in this review suggested the prognostic factors and different treatment programs that can reduce the consequences of obesity developing into adulthood. Since this is one of the first reviews of its kind, the results might prove helpful in making predictions about potential solutions to the issue of obesity and opening the door to more research into treatment strategies for reducing the adverse impacts of obesity on children.
References
WHO. (2017). Obesity. World Health Organization. Available at: https://www.who.int/health-topics/obesity. Accessed on 25 May, 2023.
Auguste A, Dugas J, Menvielle G, Barul C, Richard JB, Luce D. Social distribution of tobacco smoking, alcohol drinking and obesity in the French West Indies. BMC Public Health. 2019;19(1).
Garrido-Miguel M, Cavero-Redondo I, Álvarez-Bueno C, Rodríguez-Artalejo F, Moreno LA, Ruiz JR, Ahrens W, Martínez-Vizcaíno V. Prevalence and trends of overweight and obesity in European children from 1999 to 2016. JAMA Pediatrics 2019;173(10):e192430.
Llewellyn A, Simmonds M, Owen CG, Woolacott N. Childhood obesity as a predictor of morbidity in adulthood: A systematic review and meta-analysis. Obesity Rev. 2015;17(1):56-67.
De Onis M, Martínez-Costa C, Núñez F, Nguefack-Tsague G, Montal A, Brines J. Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk. Public Health Nutrit. 2012;16(4):625-30.
Chesi A, Grant SFA. The genetics of pediatric obesity. Trends Endocrinol Metabol. 2015;26(12):711-21.
Locke AE, Kahali B, Berndt SI. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197-206.
Pennings N, Golden L, Yashi K, Tondt J, Bays HE. Sleep-disordered breathing, sleep apnea, and other obesity-related sleep disorders: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022. Obesity Pillars. 2022;4:100043.
LeBlanc AG, Spence JC, Carson V, Connor Gorber S, Dillman C, Janssen I et al. Systematic review of sedentary behavior and health indicators in the early years (aged 0-4 years). Applied Physiol Nutrit Metabol. 2012;37(4): 753-72.
Wilfley DE, Stein RI, Saelens BE, Mockus DS, Matt GE, Hayden-Wade HA et al. Efficacy of maintenance treatment approaches for childhood overweight. JAMA 2007;298(14):1661.
Hooley M. Dental caries is related to obesity in children but the relationship is moderated by socio-economic strata and child age. J Evidence Based Dental Pract. 2014;14(1):16-8.
Singh A, Pratyusha K, Ananthu H, Parikh T, Jaiswal A, Singh H. Obesity and dental caries- A systematic review. Neuroquantology. 2022;20(15):3971-7.
Petraroli M, Castellone E, Patianna V, Esposito S. Gut microbiota and obesity in adults and children: The state of the art. Frontiers Pediatr. 2021;9.
Wehbe Chidiac C. American Academy of Pediatrics Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents with Obesity: What we can learn versus what we can apply in clinical practice. IJEDO. 2023;5:4-7.
Resnicow K, McMaster F, Bocian A, Harris D, Zhou Y, Snetselaar L et al. Motivational interviewing and dietary counseling for obesity in primary care: An RCT. Pediatrics 2015;135(4):649-57.
Taylor RW, Cox A, Knight L, Brown DA, Meredith-Jones K, Haszard JJ et al. A tailored family-based obesity intervention: A randomized trial. Pediatrics 2015;136(2):281-9.
Fried M, Yumuk V, Oppert JM, Scopinaro N, Torres A, Weiner R et al. Interdisciplinary European guidelines on metabolic and bariatric surgery. Obesity Surg. 2013;24(1):42-55.
Nobili V, Vajro P, Dezsofi A, Fischler B, Hadzic N, Jahnel J et al. Indications and limitations of bariatric intervention in severely obese children and adolescents with and without nonalcoholic steatohepatitis. J Pediatr Gastroenterol Nutr. 2015;60(4):550-61.
Bambra CL, Hillier FC, Moore HJ, Cairns-Nagi JM, Summerbell CD. Tackling inequalities in obesity: A protocol for a systematic review of the effectiveness of public health interventions at reducing socioeconomic inequalities in obesity among adults. Systematic Rev. 2013;2(1).
Waters E, de Silva-Sanigorski A, Burford BJ, Brown T, Campbell KJ, Gao Y et al. Interventions for preventing obesity in children. Cochrane Database Systematic Rev. 2011;1.
Verduci E, Bronsky J, Embleton N, Gerasimidis K, Indrio F, Köglmeier J et al. Role of dietary factors, food habits, and lifestyle in childhood obesity development: A position paper from the european society for paediatric gastroenterology, hepatology and nutrition committee on nutrition. J Pediatr Gastroenterol Nutr. 2021;72(5):769-83.
Hu D, Zhou S, Crowley-McHattan ZJ, Liu Z. Factors That Influence Participation in Physical Activity in School-Aged Children and Adolescents: A Systematic Review from the Social Ecological Model Perspective. Int J Environmental Res Publ Health. 2021;18(6):3147.
Heitkamp M, Siegrist M, Molnos S, Brandmaier S, Wahl S, Langhof H, Grallert H, Halle M. Obesity Genes and Weight Loss During Lifestyle Intervention in Children with Obesity. JAMA Pediatr. 2021;175(1):e205142.
Hüls A, Wright MN, Bogl LH, Kaprio J, Lissner L, Molnár D et al. Polygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents. Int J Obesity. 2005;2021;45(6).
O'Donnell A, Buffini M, Kehoe L, Nugent A, Kearney J, Walton J et al. Application of a composite scoring protocol to identify factors that contribute to the risk of overweight and obesity in Irish children. Pediatr Obesity. 2022;17(9);e12922.
Brambilla I, Bellanca E, Pistone C, De Filippo M, Votto M, Tondina E et al. Pediatric obesity: a mini-review for pediatrician. Acta bio-medica: Atenei Parmensis. 2022;93(S3):e2022197.
Archer E, Lavie CJ. Obesity Subtyping: The Etiology, Prevention, and Management of Acquired versus Inherited Obese Phenotypes. Nutrients. 2022:14(11):2286.
Carpena Lucas PJ, Sánchez-Cubo F, Vargas M, Mondéjar Jiménez J. Influence of Lifestyle Habits in the Development of Obesity during Adolescence. Int J Environmental Res Publ Health. 2022;19(7):4124.
Jones D, De Lucia Rolfe E, Rennie KL, Griep LMO, Kusinski LC, Hughes DJ et al. Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study. Nutrients. 2021;13(4):1156.
Kansra AR, Lakkunarajah S, Jay MS. Childhood and Adolescent Obesity: A Review. Frontiers Pediatr. 2021;8:581461.
Littleton SH, Berkowitz RI, Grant SFA. Genetic Determinants of Childhood Obesity. Molecular Diagnosis Therapy. 2020;24(6):653-63.
Panera N, Mandato C, Crudele A, Bertrando S, Vajro P, Alisi A. Genetics, epigenetics and transgenerational transmission of obesity in children. Frontiers Endocrinol. 2022;13:1006008.
Bojanic D, Ljubojevic M, Krivokapic D, Gontarev S. Waist circumference, waist-to-hip ratio, and waist-to-height ratio reference percentiles for abdominal obesity among Macedonian adolescents. Percentiles de referencia de circunferencia de la cintura, relación cintura-cadera y relación cintura-altura para la obesidad abdominal de los adolescentes macedonios. Nutricion Hospitalaria. 2020;37(4):786-93.
Alqaderi H, Hegazi F, Al-Mulla F, Chiu CJ, Kantarci A, Al-Ozairi E et al. Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents. Frontiers Publ Heal. 2022;10:800373.
Abdelhamed MH, Salah S, Lqudsi KK, Jan MM, Alahdal DK, Alfaifi SA et al. Indices of insulin resistance and adiposity can detect obesity-related morbidity in pediatrics. Saudi Med J. 2022;43(2):161-8.
Mardali F, Naziri M, Sohouli MH, Fatahi S, Sadat Hosseini-Baharanchi F, Găman M-A et al. Predictors of central and general obesity in Iranian preschool children: Which anthropometric indices can be used as screening tools? BMC Pediatr. 2022;22(1):320.
Lischka J, Schanzer A, Hojreh, A, Ba Ssalamah, A, Item CB, de Gier C et al. A branched-chain amino acid-based metabolic score can predict liver fat in children and adolescents with severe obesity. Pediatr Obesity. 2021;16(4):e12739.
Yin R, Wang X, Li K, Yu K, Yang L. Lipidomic profiling reveals distinct differences in plasma lipid composition in overweight or obese adolescent students. BMC Endocrine Disorders. 2021;21(1):2.
Tylavsky FA, Ferrara A, Catellier DJ. Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program. Int J Obesity. 2005;44(3):617-27.
Partearroyo T, Sánchez Campayo E, Puga Giménez de Azcárate AM, Angulo Díaz-Parreño S, Ávila Torres JM et al. Waist circumference as a prognostic index of childhood abdominal obesity: Findings in the Spanish population. Nutrición Hospitalaria. 2020;1.
Tao JM, Wei W, Ma XY, Huo YX, Hu MD, Li XF, Chen X. Diagnostic accuracy of anthropometric indices for discriminating elevated blood pressure in pediatric population: a systematic review and a meta-analysis. BMC Pediatr. 2022;22(1):19.
Behrooz M, Hajjarzadeh S, Kahroba H, Ostadrahimi A, Bastami M. Expression pattern of miR-193a, miR122, miR155, miR-15a, and miR146a in peripheral blood mononuclear cells of children with obesity and their relation to some metabolic and inflammatory biomarkers. BMC Pediatrics. 2023;23(1):95.
Yang Y, Zhang M, Yu J, Pei Z, Sun C, He J et al. Nationwide Trends of Pediatric Obesity and BMI z-Score From 2017-2021 in China: Comparable Findings From Real-World Mobile- and Hospital-Based Data. Frontiers in Endocrinol. 2022;13:859245.
Díaz-Rodríguez M, Pérez-Muñoz C, Carretero-Bravo J, Ruíz-Ruíz C, Serrano-Santamaría, M, Ferriz-Mas BC. Early Risk Factors for Obesity in the First 1000 Days-Relationship with Body Fat and BMI at 2 Years. Int J Environmental Res Publ Health. 2021;18(15):8179.
Wright CM, Cole TJ, Fewtrell M, Williams JE, Eaton S, Wells JC. Body composition data show that high BMI centiles overdiagnose obesity in children aged under 6 years. Am J Clin Nutr. 2022;116(1):122-31.
Genoni G, Menegon V, Monzani A, Archero F, Tagliaferri F, Mancioppi V et al. Healthy Lifestyle Intervention and Weight Loss Improve Cardiovascular Dysfunction in Children with Obesity. Nutrients. 2021;13(4):1301.
Burton ET, Smith WA. Mindful Eating and Active Living: Development and Implementation of a Multidisciplinary Pediatric Weight Management Intervention. Nutrients. 2020;12(5):1425.
Armstrong SC, Windom M, Bihlmeyer NA, Li JS, Shah SH, Story M et al. Rationale and design of "Hearts and Parks": study protocol for a pragmatic randomized clinical trial of an integrated clinic-community intervention to treat pediatric obesity. BMC Pediatr. 2020;20(1):308.
Lee AM, Szurek SM, Dilip A, Dillard JR, Miller DR, Theis RP et al. Behavioral Weight Loss Intervention Preferences of Adolescents with Overweight/Obesity. Childhood Obes. 2021;17(3):160-8.
Lei S, Inojosa JRM, Kumar S, Lee AT, Scott CG, Lerman A et al. Effectiveness of a Weight Loss Program Using Digital Health in Adolescents and Preadolescents. Childhood Obes. 2021;17(5):311-21.
Else V, Chen Q, Cortez AB, Koebnick C. Sustainability of weight loss from a family-centered pediatric weight management program integrated in primary care. BMC health services research 2022;22(1):12.
Eichen DM, Rhee KE, Strong DR, Boutelle KN. Impact of Race and Ethnicity on Weight-Loss Outcomes in Pediatric Family-Based Obesity Treatment. J Racial Ethnic Health Disparities. 2020;7(4):643-9.
Sohn MJ, Chae W, Ko JS, Cho JY, Kim JE, Choi JY et al. Metabolomic Signatures for the Effects of Weight Loss Interventions on Severe Obesity in Children and Adolescents. Metabolites. 2021;12(1):27.
Bondyra-Wiśniewska B, Myszkowska-Ryciak J, Harton A. Impact of Lifestyle Intervention Programs for Children and Adolescents with Overweight or Obesity on Body Weight and Selected Cardiometabolic Factors-A Systematic Review. Int J Environmental Res Publ Heal. 2021;18(4):2061.
Rigamonti AE, Caroli D, Grugni G, Cella SG, Sartorio A. Frequent Medical Supervision Increases the Effectiveness of a Longitudinal Multidisciplinary Body Weight Reduction Program: A Real-World Experience in a Population of Children and Adolescents with Obesity. Nutrients. 2021;13(10):3362.
Fiechtner L, Castro I, Cheng ER, Sharifi M, Gerber MW, Luo M et al. Characteristics of achieving clinically important weight loss in twopediatric weight management interventions. Pediatr Obesity. 2021;16(9):e12784.
Forseth B, Hampl S, Dreyer Gillette M, Foright RM, Gibson, M, Vandal J et al. Incorporating Yoga into a Pediatric Weight Management Program: A Pilot Study. Childhood Obesity. 2022;18(1):67-71.
Czepiel KS, Perez NP, Campoverde Reyes KJ, Sabharwal S, Stanford FC. Pharmacotherapy for the Treatment of Overweight and Obesity in Children, Adolescents, and Young Adults in a Large Health System in the US. Frontiers Endocrinol. 2020;11:290.
Schalkwijk A, Bot S, De Vries L. Perspectives of obese children and their parents on lifestyle behavior change: A qualitative study. Int J Behavioral Nutr Physical Activity. 2015;12:102.
Chen PS, Chang KC, Chang CH, Chen YT, Huang HW, Tsai SM, Yang HR, Tung YC, Wu WW, Chen HL. The effect of a multidisciplinary lifestyle modification program for obese and overweight children. J Formosan Med Asso. 2022;121(9):1773-85.
Eisenberg D, Shikora SA, Aarts E. American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for Metabolic and Bariatric Surgery. Surg Obesity Rel Dis. 2022;18(12):1345-56.
Janson A, Järvholm K, Gronowitz E, Sjögren L, Klaesson S, Engström M et al. A randomized controlled trial comparing intensive non-surgical treatment with bariatric surgery in adolescents aged 13-16 years (AMOS2): Rationale, study design, and patient recruitment. Contemporary Clin Trials Communications. 2020;19:100592.
Flores SV, Roco-Videla A, Silva-González O. Genotype frequencies and the Hardy-Weinberg equilibrium on rs9939609 FTO and rs17782313 MC4R: implications for statistical associations to overweight and obesity in children and adolescents. Nutrition. 2022;103-4.
Stanford FC, Mushannen T, Cortez P, Campoverde Reyes KJ, Lee H, Gee DW et al. Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults. Frontiers Eendocrinol. 2020;11:157.
Hilbert A, Staerk C, Strömer A, Mansfeld T, Sander J, Seyfried F, Kaiser S et al. Nonnormative Eating Behaviors and Eating Disorders and Their Associations With Weight Loss and Quality of Life During 6 Years Following Obesity Surgery. JAMA Network Open. 2022;5(8):e2226244.
Nayak AK, Gupta MK, Mayan V, Tiwari RV, Parikh T, Bombay SG. Evaluation of prevalence of cardiac risk in diabetic patients: Original research. Eur J Molecular Clin Med. 2022;9(6).
Parikh T. Prevalence and impact of Gastroesophageal Reflux Disease in Infants and Children. Int Clin Img and Med Rew. 2023;4(2):1145.
Raychaudhuri M, Sanyal D. Childhood obesity: Determinants, evaluation, and prevention. Indian J Endocrinol Metabol. 2012;16(8):192.
Mohan V, Ranjani H, Pradeepa R, Mehreen T, Anjana R, Anand K et al. Determinants, consequences and prevention of childhood overweight and obesity: An Indian context. Indian J Endocrinol Metabol. 2014;18(7):17.
Robinson N, McKay JA, Pearce MS, Albani V, Wright CM, Adamson AJ et al. The biological and social determinants of childhood obesity: Comparison of 2 cohorts 50 years apart. J Pediatr. 2021;228:138-46.
Genes and obesity. 2022. CDC. Available at: https://www.cdc.gov/genomics/resources/diseases/obesity/obesedit.htm. Accessed on 25 March, 2023.
Rossman H, Shilo S, Barbash-Hazan S, Artzi NS, Hadar E, Balicer RD et al. Prediction of childhood obesity from nationwide health records. J Pediatr. 2021;233:132-40.
Canfell OJ, Littlewood R, Wright ORL, Walker JL. i‐PATHWAY: Development and validation of a prediction model for childhood obesity in an Australian prospective birth cohort. J Pediatr Child Heal. 2021;57(8):1250-58.
Pu R, Shi D, Gan T, Ren X, Ba Y, Huo Y et al. Effects of metformin in obesity treatment in different populations: A meta-analysis. Therapeutic Adv Endocrinol Metabol. 2020;11:204201882092600.
Chanoine JP, Hampl S, Jensen C, Boldrin M, Hauptman J. Effect of orlistat on weight and body composition in obese adolescents. JAMA 2005;293(23):2873.
Kelly AS, Bensignor MO, Hsia DS, Shoemaker AH, Shih W, Peterson C et al. Phentermine/Topiramate for the treatment of adolescent obesity. NEJM Evidence 2022;1(6).
Yashi K, Daley SF. Obesity and Type 2 Diabetes. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2023.
