Myelin oligodendrocyte glycoprotein antibody associated disease – two distinct clinical presentations
Keywords:Myelin oligodendrocyte glycoprotein, Demyelinating disorder, Acute disseminated encephalomyelitis, Optic neuritis
Myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is an inflammatory demyelinating disorder caused by the development of immunoglobulin G autoantibody targeting MOG, which is expressed exclusively on the outer surface of the myelin sheath and plasma membrane of oligodendrocyte. MOGAD can present in different clinical spectrum including acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), transverse myelitis and relapsing courses of these presentations. Depending on the severity, acute attacks can be treated with I V methyl prednisolone, plasma exchange or IVIG as in any demyelinating disease. This report is about 2 children with MOG antibody positive disease who presented with different symptomatology, severity and outcome.
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