Clinical profile and outcome of multisystem inflammatory syndrome in children and adolescents related to COVID-19 in a tertiary care hospital
DOI:
https://doi.org/10.18203/2349-3291.ijcp20231504Keywords:
SARS-CoV-2, MIS-C, COVID-19, KDAbstract
The pandemic of COVID-19 initially appeared to cause only a mild illness in children. The paediatric age group comprises only less than 7% of total COVID-19 worldwide. Multi system inflammatory syndrome in children (MIS-C) is a rare, but life-threatening complication of SARS-CoV-2 infection. We report a case series of 24 children with suspicion of multisystem inflammatory syndrome related to COVID-19 were assessed using diagnostic criteria established by ministry of health and family welfare, government of India using detailed history, clinical examination and relevant laboratory investigations. Among total 24 patients ranging from 23 days to 11 years with mean age of 4.5 years includes 10 patients (41.67%) presented with mild illness, 7 patients (29.12%) with persistent fever to Kawasaki disease (KD) like illness and 7 patients (29.12%) with fatal disease with MODS and shock. These children were managed as per guidelines with modifications for individual case if necessary and includes supportive management with main stays of IVIG and steroids. Three children died.
References
WHO. Available at: https://www.who.int/publications/i/item/WHO-2019-nCoV-Sci_Brief-Children_and_adolescents-2021.1. Accessed on 23 March, 2023.
Centers for Disease Control Prevention (CDC). Emergency Preparedness and Response: Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19). Health Advisory. 2019. Available at: https://emergency.cdc.gov/han/2020/han00432.asp. Accessed on 8 March, 2023.
Guidelines for Management of COVID-19 in children. Available at: https://www.mohfw.gov.in/pdf/GuidelinesforManagementofCOVID19inCHILDREN18June2021final.pdf. Accessed on 8 March, 2023.
Hoste L, Van Paemel R, Haerynck F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Eur J Pediatr. 2021;180:2019-34.
Ahmed M, Advani S, Moreira A, Zoretic S, Martinez J, Chorath K et al. Multisystem inflammatory syndrome in children: a systematic review. EClinicalMedicine. 2020;26:100527.
World Health Organization WHO. Multisystem inflammatory Syndrome in Children and Adolescents With COVID-19: Scientific Brief. 2020. Available at: https://www.who.int/publications/i/item/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19. Accessed on 8 March, 2023.
Sai BVK, Kumar H, Arun Babu T, Chaitra R, Satapathy D, Kalidoss VK. Clinical profile and outcome of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 infection: a single-center observational study from South India. Egypt Pediatric Association Gaz. 2023;71(1):4.
Sugunan S, Bindusha S, Geetha S, Niyas HR, Kumar AS. Clinical profile and short-term outcome of children with SARS-CoV-2 related multisystem inflammatory syndrome (MIS-C) treated with pulse methylprednisolone. Indian Pediatr. 2021;58:718-22.
Godfred-Cato S, Bryant B, Leung J, Oster ME, Conklin L, Abrams J et al. Morbidity and Mortality Weekly Report Early Release/ COVID-19-associated multisystem inflammatory syndrome in children-United States, March-July 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1074-80.
Hoste L, Van Paemel R, Haerynck F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Eur J Pediatr. 2021;180:2019-34.
Dhanalakshmi K, Venkataraman A, Balasubramanian S, Madhusudan M, Amperayani S, Putilibai S et al. Epidemiological and clinical profile of pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2 (PIMS-TS) in Indian children. Indian Pediatr. 2020;57:1010-14.
Sethy G, Mishra B, Jain MK. Clinical profile and immediate outcome of multisystem inflammatory syndrome in children associated with COVID-19: a multicentric study. J Glob Infect Dis. 2021;13(4):159-63.
Kaushik S, Aydin SI, Derespina KR, Bansal PB, Kowalsky S, Trachtman R et al. Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2 infection (MIS-C): a multi-institutional study from New York City. J Pediatr. 2020;224:24-9.
Williams V, Dash N, Suthar R, Mohandoss V, Jaiswal N, Kavitha TK et al. Clinicolaboratory Profile, Treatment, Intensive Care Needs, and Outcome of Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2: A Systematic Review and Meta-analysis. J Pediatr Intensive Care. 2020;11(1):1-12.