Clinical profile and outcome of children presenting with diabetic ketoacidosis at a tertiary care hospital in Dakshina Kannada

Authors

  • Sejal J. Panakkal Department of Paediatrics, Yenepoya Medical College, Mangalore, Karnataka, India
  • Diksha Shirodkar Department of Paediatrics, Yenepoya Medical College, Mangalore, Karnataka, India
  • Praksh R. M. Saldanha Department of Paediatrics, Yenepoya Medical College, Mangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20231048

Keywords:

Diabetic keto acidosis, Metabolic disorder, HbA1C

Abstract

Background: Diabetic ketoacidosis (DKA) is the most serious metabolic disturbance of type 1 diabetes mellitus (T1DM) and about 25 to 40% of the newly diagnosed T1DM children present with DKA. This research was conducted to study the clinical profile and identify the precipitating factors at time of presentation of DKA and to correlate the type onset of disease with the severity of DKA and the treatment outcome.

Methods: Ambispective record based study of children admitted in in the paediatric ward of a tertiary care hospital with DKA between 01 July 2019 and 31 January 2022.

Results: A total of 19 patients were enrolled and the mean age of presentation was 10.79±4.17 years with a female predominance. The family history of type 2 DM was noted in 73.7% and osmotic symptoms in 68.4% of the patients. 52.6% of the patients presented in severe DKA. Mean HbA1C noted was 15.14±2.74%. Acute Kidney Injury was present in 10.5% of the patients. Pneumonia was the major precipitating factor. The average length of hospital stay was 7.42±3.27 days. There was no significant correlation with the type of onset of T1DM and the treatment outcome. There was a significant reduction in HbA1c (p<0.05) on follow-up.

Conclusions: This study highlights the need for creating awareness, early referral and timely management of T1DM presenting not only in DKA but also during the ambulatory management.

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Published

2023-04-15

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Original Research Articles