Mermaid baby or sirenomelia: a lethal congenital anomaly
DOI:
https://doi.org/10.18203/2349-3291.ijcp20231152Keywords:
Caudal regression syndrome, Fused lower limb, Mermaid syndrome, SirenomeliaAbstract
Mermaid syndrome is a very rare, lethal congenital anomaly. It is associated with other congenital anomalies and is incompatible with life. Typical clinical features are fused lower limb from perineum to ankle and single umbilical artery. Etiology is multifactorial and is extreme form of caudal regression syndrome. When diagnosed in early gestation, termination of pregnancy may be considered.
References
Reddy KR, Srinivas S, Kumar S, Reddy S, Hariprasad Irfan GM. Sirenomelia a rare presentation. J Neonatal Surg. 2012;1:7
Valenzano M, Paole ĴIR, Rossi A, Farinini D, Garlaschi G, Fulcheri E. Sirenomelia. Pathological features, antenatal ultrasonographic clues, and a review of current embryogenic theories. Hum Reprod Update. 1999;5:82-6.
González-Quintero VH, Tolaymat L, Martin D, Romaguera RL, Rodríguez MM, Izquierdo LA. Sonographic diagnosis of caudal regression in the fi rst trimester of pregnancy. J Ultrasound Med. 2002;21:1175-8.
Aslan H, Yanik H, Celikaslan N, Yildirim G, Ceylan Y. Prenatal diagnosis of caudal regression syndrome: A case report. BMC Pregnancy Childbirth. 2001;1:8.
Twickler D, Budorick N, Pretorius D, Grafe M, Currarino G. Caudal regression versus sirenomelia: Sonographic clues. J Ultrasound Med. 1993;12:323-30.
Naveena S, Mrudula C. Sirenomelia-The mermaid syndrome: A case report. IOSR J Dent Med Sci. 2013;7:01-4.
Padmanabhan R. Retinoic acid-induced caudal regression syndrome in the mouse fetus. Reprod Toxicol. 1998;12:139-51.
Sarpogs S, Headings V. Sirenomelia accompanying exposure of the embryo to cocaine. South Med J. 1992;85:545-7.
Baktar O, Benvischke K, Masliah E. Sirenomelia of an intracytoplasmic sperm injection conception: a case report and reviewofmechanism. Pediatr Dev Pathol. 2006;9:245-53.
Sadler TW, Rasmussen SA. Examining the evidence for vascular pathogenesis of selected birth defects. Am J Med Genet A. 2010;152A:2426-36.
Duesterhoeft SM, Ernst LM, Siebert JR, Kapur RP. Five cases of caudal regression with an aberrant abdominal umbilical artery: Further support for a caudal regression-sirenomelia spectrum. Am J Med Genet A. 2007;143A:3175-84.
Messineo A, Innocenti M, Gelli R, Pancani S, Lo Piccolo R, Martin A. Multidisciplinary surgical approach to a surviving infant with sirenomelia. Pediatrics. 2006;118:e220-3.