Events that occur in premature babies before death during their hospital stay

Authors

  • Rowshan Jahan Akhter Department of General Pediatrics, Bangladesh Shishu Hospital and Institute, Sher-E-Bangla Nagar, Dhaka, Bangladesh
  • Kanta Chowdhury Department of Neonatology, Bangladesh Shishu Hospital and Institute, Sher-E-Bangla Nagar, Dhaka, Bangladesh
  • Nishat Jahan Department of Neonatology, Bangladesh Shishu Hospital and Institute, Sher-E-Bangla Nagar, Dhaka, Bangladesh
  • M. Mahbubul Hoque Department of Critical Care, Bangladesh Shishu Hospital and Institute, Sher-E-Bangla Nagar, Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2349-3291.ijcp20230718

Keywords:

Preterm, Mortality, LBW, Complication

Abstract

Background: Globally, more than 80% of newborn babies die due to LBW. PT/LBW babies usually die because of complications from prematurity rather than the prematurity itself. Due to prematurity, they face several problems during their early life, like temperature control, feeding problem, poor immunity, respiratory insufficiency etc. and especially during SCANU and NICU stay they develop sepsis, NEC leading to their death. The aim of this study was to find out the events that occur before the death of premature neonates admitted in the NICU.

Methods: A retrospective study conducted in the NICU of Department of neonatology of Bangladesh Shishu Hospital and Institute, Dhaka, Bangladesh during the period from January, 2021 to December, 2021. During this period preterm babies who died were analyzed.

Result: During study period total 95 preterm babies died. Their mean± SD of birth weight was 1228.26±115.60. Majority (40%) of neonates were 28-31 weeks old and majority (59%) neonates were male. We found 27.3% had PNA, 12% had PDA, 19% had RDS and 33.6% had only prematurity during admissions. Among all neonates, 51.58% developed sepsis, 40% pneumonia, 34% pulmonary hemorrhage 20% intra ventricular hemorrhage, 25% NEC, 13.6% BPD and 12% PDA respectively and finally died.

Conclusion: In our study, 32 (33.6%) babies admitted with only prematurity and rest were admitted with other diagnosis like PNA (27.3%), RDS (19%,) PDA (12%) and CHD (9.4%). However, they finally died of Sepsis 49 (51%), Pneumonia 38 (40%), IVH 19 (20%), NEC 24 (25.2%), BPD 13 (13.6%), Pulmonary Hemorrhage 33 (34.7%).

References

Makhoul IR, Polo S, Tatiana S, Ayala L, Brian R. Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey. Clin Infect Dis. 2005;40(2):218-24.

Global Nutrition Targets 2025: Low birth weight policy brief. Available at: https://www.who.int/ publications/i/item/WHO-NMH-NHD-14.5. Accessed on 20 November 2022.

Blencowe H, Krasevec J, de Onis M, Black RE, An X, Stevens GA, et al. National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health. 2019;7(7):849-60.

Katz J, Lee AC, Kozuki N, Lawn JE, Cousens S, Blencowe H, et al. Mortality risk in preterm and smallfor-gestational-age infants in low-income and middle-income countries: a pooled country analysis. Lancet. 2013;382(9890):417-25

Mahumud RA, Sultana M, Sarker AR. Distribution and determinants of low birth weight in developing countries. J Prev Med Public Health. 2017;50(1):18.

National Institute of Population Research and Training, Mitra and Associates, and ICF International. Available at: https://microdata.worldbank.org/index. php/catalog/1538. Accessed on 20 November 2022.

Bangladesh Demographic and Health Survey 2014. Available at: https://microdata.worldbank.org. Accessed on 20 November 2022.

Bangladesh Demographic and Health Survey 2017–18: Key Indicators. Available at: https://www.aids datahub.org/resource/bangladesh-demographic-and-health-survey-2017-18. Accessed on 20 November 2022.

World Health Assembly. Available at: https://www. who.int/about/governance/world-health-assembly. Accessed on 20 November 2022.

Goldenberg RL, Muhe L, Saleem S, Dhaded S, Goudar SS, Patterson J, et al. Criteria for assigning cause of death for stillbirths and neonatal deaths in research studies in low-middle income countries. J Matern Fetal Neonatal Med. 2019;32:1915-23.

Mengesha HG, Sahle BW. Cause of neonatal deaths in Northern Ethiopia: a prospective cohort study. BMC Public Health. 2017;17:62.

Lawn J, Cousens S, Zupan J. 4 million neonatal deaths: when? where? why? Lancet. 2005;365:891-900.

Muhe LM, McClure EM, Nigussie AK, Mekasha A. Major causes of death in preterm infants in selected hospitals in Ethiopia (SIP): a prospective, cross-sectional, observational study. Lancet Glob Health. 2019;7(8):e1130-8.

Al-Sheyab NA, Khader YS, Shattnawi KK, Alyahya MS, Batieha A. Rate, risk factors, and causes of neonatal deaths in jordan: analysis of data from jordan stillbirth and neonatal surveillance system. Front Public Health. 2020;8:595379.

Eshete A, Alemu A, Zerfu TA. Magnitude and Risk of Dying among Low Birth Weight Neonates in Rural Ethiopia: A Community-Based Cross-Sectional Study. Int J Pediatr. 2019;2019:9034952.

Neupane D, Dawson P, Houston R, Dhakal L, Sharma J, Gargi K, Kallestrup P. Lower mortality is observed among low birth weight young cv who have received home-based care by female community health volunteers in rural Nepal. BMC Preg Childbirth. 2017;17(1):23-9.

Kiatchoosakun P, Jirapradittha J, Paopongsawan P, Techasatian L, Lumbiganon P, Thepsuthammarat K, Sutra S. mortality and comorbidities in extremely low birth weight Thai infants: a nationwide data analysis. Children. 2022;9(12):1825.

Schindler T, Koller-Smith L, LuiK. Causes of death in very preterm infants cared for in neonatal intensive care units: a population-based retrospective cohort study. BMC Pediatr. 2017;17:59.

Downloads

Published

2023-03-27

Issue

Section

Original Research Articles