Epidemiological factors and clinical profile of meconium aspiration syndrome in newborns admitted in rural tertiary centre
DOI:
https://doi.org/10.18203/2349-3291.ijcp20230346Keywords:
Meconium-stained amniotic fluid, Meconium aspiration syndrome, Clinical profile, Hypoxic ischemic encephalopathyAbstract
Background: Meconium aspiration syndrome is a severe life-threatening illness in the neonate and is a major cause of perinatal morbidity and mortality. MSAF is reported around 10 to 20% of live births in which MAS seen around 5-10%. Various maternal and neonatal factors have been found associated with MAS which lead to several complications in the neonates and succumb to the disease.
Methods: The present study is a observational study was done on 59 babies admitted in NICU of Government medical college, Chidambaram for a period of 1 year and 2 months who fulfilled the clinical criteria for diagnosing MAS. Babies born with MSAF were resuscitated as per NRP guidelines and observed for their immediate outcome.
Results: Out of 460 MSAF babies, 59 developed MAS with incidence of (12.8%). MAS was common with thick meconium (55.9%) compared to thin with male preponderance (54.2%) and Primi gravida (74.6%). MAS occurred more in babies having fetal distress and antenatal risk factors like PIH, PROM, and anaemia. MAS was common in babies born through normal vaginal delivery and in term gestation of 37-40weeks with mean birth weight of 2860±394. 1minute APGAR score less than 7 in (57.6%) MAS babies and most common complications were PPHN, seizures and pneumothorax. Mortality in MAS was around (13.5%) with most common cause was hypoxic ischemic encephalopathy.
Conclusion: Babies with MAS requires proper diagnosis and careful decisions are made about the timely intervention which reduces morbidity and mortality.
References
Parker TA, Kinsella JP. Avery’s diseases of the newborn. In: Gleason CA, Juul SE, editors. Avery’s diseases of the newborn. 10th ed. Philadelphia: Elsevier Inc.; 2018:668-73.
Trimmer KJ, Gilstrap LC. Meconiumcrit and birth asphyxia. Am J Obstet Gynecol. 1991;165(4):10103.
Cleary GM, Wiswell TE. Meconium-stained amniotic fluid and the meconium aspiration syndrome: An update. Pediatr Clin North Am. 1998;45(3):511-29.
Sarah M. Managements of meconium stained liquor. Cyprus: RCOG Publisher; 2016:10.
Cloherty JP. Meconium aspiration, manual of neonatal care. USA: MSD publisher; 2015:429-34.
Uniyal P, Kalra BP, Wasim S. A study of profile of meconium aspiration syndrome in relation with birth weight and gestational age of newborns and their immediate outcome. Int J Contemp Pediatr 2021;8:1021-6.
Kumar S, Akhouri MR. An observational study of meconium aspiration syndrome and its immediate outcome with relation to thick and thin meconium stained amniotic fluid. Int J Contemp Pediatr. 2018;5:552-6
Ramanathan R, Raghuram AS. Etiological factors, clinical profile and outcome of meconium aspiration syndrome in newborn. J Med Sci Clin Res. 2017;5(5):23-9.
Phirke DS, Shah B, Ranee D. A study of the probable risk factors for meconium aspiration syndrome. Med Pulse Int J Pediatr. 2017;3(1):12-5.
Sasivarathan R, Anand AL. Etiological factors, clinical profile and outcome of meconium aspiration syndrome babies. Int J Contemp Pediatr. 2019;6(4):1515.
Hirani G, Kaur R, Basanth KGR, Guru PG, Aradhya GH. A Study on clinical profile of meconium aspiration syndrome in relation to gestational age and birth weight and their immediate outcome. RGUHS J Med Sci. 2015;5(3):60-5.
Narang A, Nair PM, Bhakoo ON, Vashisht K. Management of meconium stained amniotic fluid: A team approach. Ind Pediatr. 1993;30:9-13.
Naqvi SB, Manzoor S. Association of meconium stained amniotic fluid with perinatal outcome in pregnant women of 37-42 weeks gestation. Pak J Surg. 2011;27(4):292-8.
Fischer C, Rybakowski C, Ferdynus C, Sagot P, Gouyon JB. A Population-Based Study of Meconium Aspiration Syndrome in Neonates Born between 37 and 43 Weeks of Gestation. Int J Pediatr. 2012;2012:321545.
Balchin I, Whittaker JC, Lamont RF, Steer PJ. Maternal and fetal characteristics associated with meconium-stained amniotic fluid. Obstet Gynecol. 2011;117(4):828-35.
Eiden RD, Seifert LS, Winegar A. Peinatal characteristics of uncomplicated postdate pregnancies. Obstet Gynecol. 1987;69(3):296-9.
Firdaus US, Sachdeva S. Maternal and neonatal factors associated with meconium stained amniotic fluid. Curr Pediatr Res. 2013;17(1):37-40.
Rossi EM, Philipson EH, Williams TG, Kalhan SC. Meconium aspiration syndrome. Intrapartum and neonatal attributes. Am J Obst Gynecol. 1989;161(5):1106-10.
Gregery GA, Charles A, Rodrich. Meconium aspiration in infants; a Prospective study. J Pediatr. 1974;85:848.
Manivannan V, Murugan JR, Devandiran RS. A study on clinical profile of meconium aspiration syndrome in relation to gestational age and birth weight and their immediate outcome. Int J Contemp Pediatr. 2019;6:2346-51.
