Clinical, biochemical and echocardiographic characteristics in children with multisystem inflammatory syndrome associated with coronavirus disease: a tertiary care experience


  • Lorraine A. C. Fernandes D’Sa Department of Pediatrics, Goa Medical College, Bambolim, Goa, India
  • Vaishali Joshi Department of Pediatrics, Goa Medical College, Bambolim, Goa, India



COVID-19, MIS-C, Kawasaki disease, IVIG, Methylprednisolone


Background: We describe the clinical, biochemical and echocardiographic characteristics in children diagnosed with multisystem inflammatory syndrome (MISC) temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-Co-V-2), admitted to a tertiary care hospital in Goa, India.

Methods: This was a retrospective observational study conducted at Goa Medical College, Goa, India. Parameters including demographics, clinical features, laboratory markers, medications and outcomes were obtained from patient hospital records; analyzed for patients treated for MISC (as per WHO case definition) for a period of 11 months from 01 July 2020 to 31 July 2021.

Results: 30 patients (18 males) with median age of 7 years (IQR: 2 months – 12 years) were included. The proportion of children with gastrointestinal symptoms was 20 (64.5%), shock was a presenting feature in 15 (48%) and coronary ectasia and/or low ejection fraction was seen in 12 children (38.7%).

Conclusions: A high index of suspicion for the diagnosis of MIS-C in children presenting with fever and Kawasaki disease like symptoms or signs of shock is recommended; since early aggressive therapy with Intravenous Immunoglobulins and methylprednisolone can have favourable outcomes.

Author Biographies

Lorraine A. C. Fernandes D’Sa, Department of Pediatrics, Goa Medical College, Bambolim, Goa, India

Assistant Professor in Department of Pediatrics

Vaishali Joshi, Department of Pediatrics, Goa Medical College, Bambolim, Goa, India

Professor and Head, Department of Pediatrics


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