Clinico-epidemiological study and laboratory profile of acute viral hepatitis in children of the age group 6 months to 12 years admitted in a tertiary care hospital


  • Bidyut K. Khuntdar Department of Pediatrics, Tamralipto Government Medical College, Tamluk, West Bengal, India
  • Biplab K. Gayen Department of General Medicine, Midnapore Medical College, Midnapore, West Bengal, India
  • Surjit Naik Department of Pediatrics, Bhima Bhoi Medical College and Hospital, Balangir, Odisha, India
  • Manabendra Sau Department of Community Medicine, R. G. Kar Medical College and Hospital, Kolkata, West Bengal, India
  • Kajal K. Patra Department of Gynaecology and Obstetrics, Gouri Devi Institute of Medical Science, Durgapur, West Bengal, India
  • Anupama Nair Department of Pediatrics, Midnapore Medical College, Midnapore, West Bengal, India
  • Kishore P. Madhwani Health and Wellness Consultant, Mumbai, Maharashtra, India



Children, Clinical profile, Hepatotropic, Viral hepatitis


Background: Viral hepatitis is a major public health issue throughout the world affecting millions of children despite the availability of vaccines, prophylactic measures and improved sanitation. The objective of the study was to determine the etiological profile of acute viral hepatitis in patients admitted in a tertiary care hospital, West Bengal, India.

Methods: This prospective hospital-based study was done in, Midnapore Medical College, Paschim Medinipur, West Bengal, India from February 2020 to July 2021. Children between 6 months to 12 years who presented with fever and prodromal symptoms, with or without jaundice, abdominal pain, high coloured urine, pale coloured stools with suspicion of acute viral hepatitis were included in the study. The data were statistically analysed using Microsoft excel and statistical package for the social sciences (SPSS) software.

Results: Majority of the study subjects were from Lower middle class i.e. 59.6%. Only 34.6% regularly boiled water before consuming. Majority 44.2% of the subjects had history of practicing unhealthy eating practices which included not cleaning hands before eating. 66.7% subjects did not boiled water before consumption, 33.3% were involved in unhygienic food habits and 100% were using unhygienic sanitary practices. Prevalence of hepatitis A in our study was 96.2%. and hepatitis E was 5.8%. Prevalence of HAV IgM positive was 96.2%, prevalence of hepatitis A virus (HAV) and hepatitis E virus (HEV) positive was 1.9% and prevalence of HEV IgM positive was 5.8%.

Conclusions: Prevalence of hepatitis A in our study was 96.2%. Hence, HAV was the most common etiological factor causing acute viral hepatitis in children. It’s important to create awareness in the society regarding preventive measures like hygienic food practices and improved sanitation which is of utmost importance in its prevention.



World Health Organization. Hepatitis A. Available at: Accessed 10 October 2022.

Lemon SM. Hepatitis A virus. In: Webster RG and Granoff A, editors. Encyclopedia of Virology, London, Academic Press Ltd. 1994;546-54.

Stapleton JT, Lemon SM. Hepatitis A and hepatitis E. In: Hoeprich PD, Jordan MC, and Ronald AR, eds. Infectious Diseases, 5th edition. Philadelphia, Lippincott Co. 1994;790-7.

Kliegman R, Geme S, Shah B. Nelson textbook of pediatrics. 21st edition. Philadelphia: Elsevier. 2020;2106.

Acharya SK, Batra Y, Bhatkal B. Sero epidemiology of hepatitis A virus infection among school children in Delhi, implications for HAV vaccination. J Gastroenterol Hepatol. 2003;18:8227.

Sood V, Lal BB, Gupta E, Khanna R, Siloliya MK, Alam S. Hepatitis A virus-related pediatric liver disease burden and its significance in the Indian subcontinent. Indian Pediatr. 2019;56:741-4.

Girish N, Sunil B, Devaranavadagi RA. A clinical study of viral hepatitis in children: a prospective hospital-based study. Int J Contemp Pediatr. 2018;5:563-8.

Parekh Z, Modi R, Banker D. Clinical study of hepatitis in children with special reference to viral markers. NHL J Med Sci. 2013;2(1):23-7.

Poddar U, Thapa BR, Prasad A, Singh K. Changing spectrum of sporadic acute viral hepatitis in Indian children. J Trop Pediatr. 2002;48(4):210-3.

Kc S, Sharma D, Poudyal N, Basnet BK. Acute viral hepatitis in pediatric age groups. JNMA J Nepal Med Assoc. 2014;52(193):687-91.

Behera MR, Patnaik L. Clinico-biochemical profile and etiology of acute viral hepatitis in hospitalized children: a study from Eastern India. Indian J Child Health. 2016;3(4):317-20.

Kamath SR, Sathiyasekaran M, Raja TE, Sudha L. Profile of viral hepatitis A in Chennai. Indian Pediatr. 2009;46(7):642-3.

Moon HW, Cho JH, Hur M, Yun Y-M, Choe WH, Kwon SY, Hong LC. Laboratory characteristics of recent hepatitis A in Korea: Ongoing epidemiological shift. World J Gastroenterol. 2010;16(9):1115-8.

Kliegman RM, Stanton BF, Geme JWS, Schor NF. Nelson Textbook of Pediatrics: 20th edition page. 2016;1926-45.

Dhak S, Banerjee S. Clinico-Epidemiological Study and Laboratory Profile of Viral Hepatitis-A in Children. JMSCR. 2019;7(9):571-8.

Ghosh T, Choudhury J, Rath D, Mohanty MD. Clinical and Laboratory Profile of Acute Viral Hepatitis in Children-A Prospective Observational Study. Int J Adv Sci Technol. 2020;29(8s):2658-70.






Original Research Articles