Role of consanguinity in paediatric neurological disorders
DOI:
https://doi.org/10.18203/2349-3291.ijcp20162369Keywords:
Consanguinity, Recessive genes, Neurological disordersAbstract
Background: A marriage is said to be consanguineous, where the marriages are solemnized among persons descending from the same stock or common ancestor with close biological relations. The aim of the study was to role of consanguinity in paediatric neurological disorders.
Methods: The cases of the present study were selected from various units of paediatric ward in Velammal medical college hospital, Madurai, Tamilnadu, India, over a period of 2 years between Nov-2013 to oct-2015. This is a prospective observational study of 152 children, out of which 83 children were products of non-consanguineous with neurological disorders and 69 children were products of consanguineous marriage with neurological disorders, confirmed by history and clinical examination and correlated with appropriate investigations.
Results: It was found that out of 152 neurological cases admitted, during the study period, 69 (45.3%) of patients were products of consanguineous marriage and 83 (54.6%) were products of non-consanguineous marriage. Out of 69 cases that were product of consanguineous marriage, 27 cases (39.1%) born of second degree consanguinity and 42 cases (60.8%) were products of third degree consanguinity. Out of the 69 cases, 7 (10.1 %) of them had siblings with similar neurological problems. The prevalence of seizure disorder was 27 (17.7%), developmental delay 13 (8.5%), isolated speech delay 2 (1.3%), hearing impairment 5 (3.2%), mental retardation 11 (7.2%), visual impairment 2 (1.3%), ataxia telangiectasia 2 (1.3%) among the products of consanguineous marriage. The above stated prevalence of neurological disorders being slightly higher than that of the products of non-consanguineous marriage.
Conclusions: It is important to prevent hereditary diseases that are associated with consanguineous marriage through public education.
References
Mehndiratta MM, Paul B, Mehndiratta P. Arranged marriage, consanguinity and epilepsy. Neurology Asia. 2007;12:15-7.
Jain S. Consanguinity and inherited epilepsies. Neurology Asia. 2011;16:11-2.
Modell B, Darr A. Genetic counselling and customary consanguineous marriage. Nature review/genetics. 2002;3:225-9.
Ladoure G. Clinical and genetic studies of hereditary neurological disorders in Mali. Human Heredity and Health in Africa 2013; NIH Report.
Babtain FA. Do marital habits affect epilepsy classifications and etiology? Update from epilepsy Registry. American Journal of medicine and medical sciences. 2014;4:96-101.
Amudha S, Aruna N, Rajangam S. Consanguinity and chromosomal abnormality. Indian Journal of Human Genetics. 2005;11:108-10.
Amini SR. Consanguineous marriage among the parents of hearing impaired students in Mashhad. Iranian Rehabilitation Journal. 2010;8:36-9.
Nazarabadi MH. The relation between consanguineous marriage and mental retardation of the offspring. Medical Journal of the Islamic Republic of Iran. 2008;22:156-68.
Saad HA, Elbedour S, Tennbaun A. Consanguineous marriage and Intellectual and Developmental Disabilities among Arab Bedouins children of the Negev Region in Southern Israel: A pilot study. Frontiers in public health. 2014;2:1-39.
Bittles A. Consanguinity and Intellectual and developmental Disabilities. Eurogene 2012. http://eurogene.open.ac.uk.
Ramasundrum V, Tan CT. Consanguinity and risk of epilepsy. Neurology Asia. 2004;9:10-1.
Pooya AAA. Epilepsy and consanguinity in shiraz, Iran. Eur J pediatric Neurol 2005;9:383-6.
Kumar R, Bhava A, Bhargava R, Agarwal GG. Prevalence and risk factors for neurological disorders in children aged 6 months to 2 years in northern India. Dev med child Neurol. 2013;55:348-56.
Moin M, Aghamohammadi A, Kouhi A, Tavassoli S, Rezaei N, Ghaffari SR, et al. Ataxia –Telangiectasia in Iran: clinical and Laboratory features of 104 patients. Pediatric Neurol. 2007;37:21-8.
Nath A, Patil C, Naik VA. Prevalence of consanguineous marriage in a rural community and its effect on pregnancy outcome. Indian Journal of community medicine. 2004;29:41-3.
Saad AR, Bademosi O, Ismail H, Awada A, Dawodu A, Freihi HA. A community survey of neurological disorders in Saudi Arabia: the Thugbah study. Neuroepidemiology. 1993;12(3):164-78.
Mosayebi Z, Movahedian AH. Pattern of congenital malformations in consanguineous versus non- consanguineous marriages in Kashan, Islamic of Iran. Eastern Mediterranean Health Journal. 2007;13:868-75.
Devi ACP, Sudarsanam D. Role of consanguinity in Mental Retardation. Asian J Exp Biol Sci. 2011;2:162-4.
