Published: 2022-04-25

Serum glutamic-oxaloacetic transaminase and serum glutamic pyruvic transaminase ratio as an early predictor to assess dengue severity

Sarala Sabapathy, Chaithrashree Rajanna, Rasmika Das K., Nithin Raj Muniraju Geetha, Nikhitha S. Thampi


Background: Dengue fever is a benign syndrome caused by arthropod borne viruses which is transmitted by infective bite of a particular mosquito known as Aedes aegypti, a day time biting mosquito, which is the principal vector of the disease. Although liver is not a major target organ, hepatic dysfunction is well recognised and can be used as an early predictor to assess the dengue severity by looking at the ratio of serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) levels. Studies using SGOT/SGPT ratio to assess severity of dengue were  very few, hence the need for the study.

Methods: Ratio of SGOT and SGPT is considered as an early predictor to assess severity of dengue in children admitted under department of paediatrics at Sapthagiri Institute of Medical Sciences and Research Centre, Bangalore. A total of 100 children aged between 0-15 years were admitted with signs and symptoms of dengue. Informed consent was obtained and detailed history was taken. For all cases, dengue serology rapid and ELISA was done at our hospital. Children positive for NS1, IgM, IgM+ IgG were included in the study and ratio of SGOT/SGPT done at the time of admission was taken and followed up for clinical profile.

Results: Children with SGOT/SGPT ratio<1 at the time of admission had lesser duration of hospital stay and complications when compared to children with SGOT/SGPT ratio >1.

Conclusions: SGOT/SGPT ratio at the time of admission can be used to predict dengue severity, duration of hospital stay and outcome.



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Peter G, Micheal DR. Principles of Drug Therapy., Behrman K, Stanton J, editors. Nelson Text Book of Paediatrics. 21st edition vol 1. Philadelphia: Saunders Elsevier. 2016;1760-64.

Parthasarthy A, Menon PSN, Nair MKC. IAP Text Book of Paediatrics. 7th edition. Immunity, Immunisation and Infectious Diseases. 2019;310-34.

Waggoner JJ, Gresh L, Vargas MJ, Ballesteros G, Tellez Y, Soda KJ et al. Viremia and clinical presentation in Nicaraguan patients infected with Zika virus, chikungunya virus, and dengue virus. Clin Infect Dis. 2016;30:ciw589.

World Health Organization, Special Programme for Research, Training in Tropical Diseases, World Health Organization. Department of Control of Neglected Tropical Diseases, World Health Organization. Epidemic, Pandemic Alert. Dengue: guidelines for diagnosis, treatment, prevention and control. Available at: Accessed on 14 March 2022.

Gajera VV, Sahu S, Dhar R. Study of haematological profile of dengue fever and its clinical implication. Ann Applied Bio-Sci. 2016;3(3):A241-6.

Athira PP, Jagan OA, Umadevi P, Pragnatha K, Veena PM. A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India. J Clin Diagnostic Res. 2018;12(7).

PaiJakribettu R, Boloor R, Thaliath A, George SY, George T, Rai MP et al. Correlation of clinic-haematological parameters in paediatric dengue: a retrospective study. J Trop Med. 2015;24:2015.

Jain H. Clinical profile and outcome of dengue fever in hospitalized children of South Rajasthan, India. Int J Contemp Pediatr. 2016;3(2):546-9.

Saraswathy MP, Sankari K, Sakthi G, Sripriya D, Lakshmi P. Incidence of dengue hemorrhagic fever in children: a report from Melmaruvathur Tamil Nadu, India. J Pharm SciInnov. 2013;2(1):34-6.

Bhave S, Rajput C, Bhave S. Clinical profile and outcome of dengue fever and dengue haemorrhagic fever in paediatric age group with special reference to WHO guidelines (2012) on fluid management of dengue fever. Int J Adv Res. 2015;3(4):196-201.

Pongpan S, Wisitwong A, Tawichasri C, Patumanond J. Prognostic indicators for dengue infection severity. Int J Clin Pediatr. 2013;2(1):12-8.

Bokade CM, Chauhan U, Kamat P. Study of Hepatic Dysfunction In Dengue Fever And It’s Predictor of Outcome. Int J Recent Sci Res. 2016;7(9):13360-63.

Zubair A, Qureshi AA, Jafri SA. Assessment of Dengue Fever Severity Through Liver Function Test. In Dengue-Immunopathology and Control Strategies. 2017;26.

Bandyopadhyay D, Chattaraj S, Hajra A, Mukhopadhyay S, Ganesan V. A study on spectrum of hepatobiliary dysfunctions and pattern of liver involvement in dengue infection. J Clin Diagnostic Res. 2016;10(5):OC21.

Selvan T. Study of prevalence and Hepatic dysfunction in Dengue fever in children. Liver. 2015; 9(11):14-8.