Acute disseminated encephalomyelitis in SARS-CoV2 seropositive child
Keywords:Diplegia, ADEM, SARS-CoV2
In this case report, a 2-year-old boy presented with UMN type of diplegia with involvement of cerebral cortex. He was afebrile with normal inflammatory markers, negative RT-PCR throat swab, negative COVID IgM and positive IgG antibodies with CSF showing elevated proteins with lymphocytosis on a background of MRI brain depicting a picture of white matter hyperintense signals on T2 FLAIR and resolution on follow-up MRI which confirms the possibility of acute disseminated encephalomyelitis (ADEM) following recent SARS-CoV2 infection.
Desai I, Manchanda R, Kumar N, Tiwari A, Kumar M. Neurological manifestations of coronavirus disease 2019: exploring past to understand present. Neurol Sci. 2021;42(3):773-85.
Sahu P, Ritu. Acute disseminated encephalomyelitis in a SARS-CoV2 seropositive child. Indian J Child Health. 2021;8(7):249-51.
Robert K, Bonita FMDS, Joseph SG, Nina FS. Nelson Textbook of Pediatrics. Edition 20. Philadelphia, PA: Elsevier. 2016.
Alper G. Acute Disseminated Encephalomyelitis. J Child Neurol. 2012;27(11):1408-25.
Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 1995;80(5):695-705.