Acute disseminated encephalomyelitis in SARS-CoV2 seropositive child

Authors

  • Arul Prasath S. V. Department of Paediatrics, Kanyakumari Government Medical College, Asaripallam, Tamil Nadu, India
  • Rini Evangeline J. Department of Paediatrics, Kanyakumari Government Medical College, Asaripallam, Tamil Nadu, India
  • Steeve Gnana Samuel Department of Paediatrics, Kanyakumari Government Medical College, Asaripallam, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20220771

Keywords:

Diplegia, ADEM, SARS-CoV2

Abstract

In this case report, a 2-year-old boy presented with UMN type of diplegia with involvement of cerebral cortex. He was afebrile with normal inflammatory markers, negative RT-PCR throat swab, negative COVID IgM and positive IgG antibodies with CSF showing elevated proteins with lymphocytosis on a background of MRI brain depicting a picture of white matter hyperintense signals on T2 FLAIR and resolution on follow-up MRI which confirms the possibility of acute disseminated encephalomyelitis (ADEM) following recent SARS-CoV2 infection.

Author Biography

Arul Prasath S. V., Department of Paediatrics, Kanyakumari Government Medical College, Asaripallam, Tamil Nadu, India

Junior Resident

Department of Paediatrics

References

Desai I, Manchanda R, Kumar N, Tiwari A, Kumar M. Neurological manifestations of coronavirus disease 2019: exploring past to understand present. Neurol Sci. 2021;42(3):773-85.

Sahu P, Ritu. Acute disseminated encephalomyelitis in a SARS-CoV2 seropositive child. Indian J Child Health. 2021;8(7):249-51.

Robert K, Bonita FMDS, Joseph SG, Nina FS. Nelson Textbook of Pediatrics. Edition 20. Philadelphia, PA: Elsevier. 2016.

Alper G. Acute Disseminated Encephalomyelitis. J Child Neurol. 2012;27(11):1408-25.

Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 1995;80(5):695-705.

Downloads

Published

2022-03-24

Issue

Section

Case Reports