DPT immunization and SIDS


  • Kalyani Srinivas Department of Pediatrics, Government Medical College, Nizamabad, Telangana, India
  • G. Preeti Department of Pediatrics, Government Medical College, Nizamabad, Telangana, India
  • Sujatha Pasula Department of Biochemistry, Katuri Medical College, Guntur, Andhra Pradesh, India




SIDS, DPT vaccination, Benefits


Background: Aim of this study was to determine whether DTP increased the risk of sudden infant death syndrome in children.

Methods: Present case-control study was done in Andhra Pradesh at all medical centers in outpatient and inpatient, who have scheduled vaccination from the time of birth from 2012 to 2014.

Results: It is found that mortality with SIDS in the period zero to three days following DTP to be 6.9 times that in the period beginning 30 days after immunization (95 per cent confidence interval, 1.4 to 28). The mortality rate of non-immunized infants was 4.5 times that of immunized infants of the same age (95 per cent CI, 1.9 to 12). Although the mortality ratios for SIDS following DTP is less as the period of time of vaccination increase, so that only a few cases of SIDS in infants could be due to DTP vaccine.

Conclusions: Present study agrees that benefit of DPT vaccination is more than risk associated with SIDS. It is conclude that there is no increased risk of SIDS with immunization with DTP.


Christopher P. Howson, Cynthia J. Howe, Harvey V. A report of the committee to review the adverse consequences of pertussis and rubella vaccines. In: Christopher P. Howson, Cynthia J. Howe, Harvey V. Fineberg, eds. Institute of Medicine: Adverse Effects of Pertussis and Rubella Vaccines. Washington (DC): National Academies Press (US); 1991;382:6-9.

Peter G. Report of the committee on infectious diseases. In: Peter G, eds. American Academy of Pediatrics. The Red Book. 20th ed. Elk Grove Village, IL: American Academy of Pediatrics; 1986.

Cody CL, Baraff LJ, Cherry JD, March SM, Manclark CR. Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children. Pediatrics. 1981;68:650-60.

Miller DL, Ross EM, Aldershade R, Bellman MH, Rawson NSB. Pertussis immunization and serious acute neurological illness in children. Br Med J. 1981;282:1595-9.

Byard RW, Buorne AJ, Burnell RH, Roberton DM. No association between DTP vaccination and SIDS. Med J Aust. 1991;155:135-6.

Mitchell EA, Stewart AW, Clements M, Ford RPK on behalf the New Zealand Cot Death Study Group. Immunisation and the sudden infant death syndrome. Arch Dis Child. 1995;73:498-501.

Jonville-BeÂra AP, Autret E, Laugier J. Sudden infant death syndrome and diphtheria-tetanus-pertussis-poliomyelitis vaccination status. Fundam Clin Pharmacol. 1995;9:263-70.

Haglund B, Cnattingius S. Cigarette smoking as a risk factor for Sudden Infant Death Syndrome: a population based study. Am J Public Health. 1990;80:29-32.

Grether JK, Schulman J. Sudden infant death syndrome and birth weight. J Pediatr. 1989;114:561-7.

Stewart GT. Infection and immunization. Scot Med J. 1979;24:47-52.

Hoffman HJ, Hunter JC, Hasselmeyer EG. SIDS and DTP. In: Hoffman HJ, Hunter JC, Hasselmeyer EG, eds. Proceedings of the 17th Immunization Conference. Atlanta, GA: Conference; May 1982.

Taylor EM, Emery JL. Immunization and cot deaths (letter). Lancet. 1982;2:721.

Baraff LJ, Ablon WJ, Weiss RC. Possible temporal association between diphtheria tetanus toxoid-pertussis vaccination and sudden infant death syndrome. Pediatr Infect Dis. 1983;2:7-11.

Solberg LK. DPT vaccination, visit to child health center and sudden infant death syndrome (SIDS); evaluation of DPT vaccination. Oslo Health Council. NIH Library Translation NIH-85-152. Bethesda: CR Manclark, Laboratory of Pertussis, Food and Drug Administration; 1985.

Walker AM, Jick H, Perera DR, Thompson RS, Knauss TA. Diphtheria-tetanus-pertussis immunization and sudden infant death syndrome. Am J Public Health. 1987;77: 945-51.

Hoffman HJ, Hunter JC, Damus K, Pakter J, Peterson DR, van Belle G, et al. Diphtheriatetanus-pertussis immunization and sudden infant death: results of the National Institute of Child Health and Human Development Cooperative Epidemiological Study of sudden infant death risk factors. Pediatrics. 1987;79:598-611.

Hoffman HJ, Damus K, Hillman L, Krongrad E. Risk factors for SIDS: results of the National Institute of Child Health and Human Development SIDS cooperative epidemiological study. Ann NY Acad Sci. 1988;533:13-30.

Griffin MR, Ray WA, Livengood JR, Schaffner W. Risk of sudden infant death syndrome after immunization with the diphtheria-tetanus-pertussis vaccine. N Engl J Med. 1988;319:618-23.






Original Research Articles