Posterior reversible encephalopathy syndrome seen in a case of acu tepost-streptococcal glomerulonephritis: a case report
DOI:
https://doi.org/10.18203/2349-3291.ijcp20220100Keywords:
Acute glomerulonephritis, Childhood, Posterior reversible encephalopathy syndromeAbstract
Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological condition that involves the acute onset of headache, confusion, optical impairments, and seizures with accompanying vasogenic edema on brain imaging. Here is a 12 years old male patient presented with complaints of swelling in the face and legs, headache and vomitings. He had a history of fever, sore throat and tonsillitis 12 days back. On physical examination weight and height of the patient was between 25-50th percentile, BP was 142/92 mmHg (>99th centile), he had pretibial +2 edema and periorbitol edema. At presentation urine analysis showed haematuria, proteinuria at nephritic level, elevated urea and creatinine, increased ASO titre, low C3 and C4 levels. After admission, he had an episode of convulsion when BP was 162/98 mm hg. Magnetic resonance imaging brain showed bilateral occipital, parietal, frontal cortex and subcortical white matter T2/Fluid-attenuated inversion recovery (FLAIR) hyperintensitie, suggestive of PRES. EEG was found to be normal. MRI was found to be normal in the first month after starting on antihypertensive and anticonvulsive treatment. In the first year of the follow-up, the blood pressure, neurological examination and urinalysis findings were found to be normal. Thus, it is suggested that early diagnosis of PRES in patients with clinical features and prompt treatment will prevent permanent neurologic sequale.
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References
Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996;334(8):494-500.
Wirrell EC, Hamiwka LD, Hamiwka LA, Grisaru S, Wei X. Acute glomerulonephritis presenting with PRES: a report of 4 cases. Can J Neurol Sci. 2007;34(3):316-21.
Tetsuka S, Ogawa T. Posterior reversible encephalopathy syndrome: A review with emphasis on neuroimaging characteristics. J Neurol Sci. 2019;404:72-9.
Endo A, Fuchigami T, Hasegawa M, Hashimoto K, Fujita Y, Inamo Y, et al. Posterior reversible encephalopathy syndrome in childhood: report of four cases and review of the literature. Pediatr Emerg Care. 2012;28(2):153-7.
Yamada A, Ueda N. Age and gender may affect posterior reversible encephalopathy syndrome in renal disease. Pediatr Nephrol. 2012;27(2):277-83.
Soylu A, Kavukçu S, Türkmen M, Akbaş Y. Posterior leukoencephalopathy syndrome in poststreptococcal acute glomerulonephritis. Pediatr Nephrol. 2001;16(7):601-3.
Prasad N, Gulati S, Gupta RK, Sharma K, Gulati K, Sharma RK, et al. Spectrum of radiological changes in hypertensive children with reversible posterior leucoencephalopathy. Br J Radiol. 2007;80(954):422-9.
Gupta S, Goyal VK, Talukdar B. Reversible posterior leucoencephalopathy syndrome in post streptococcal glomerulonephritis. Indian Pediatr. 2010;47(3):274-6.
Ishikura K, Hamasaki Y, Sakai T, Hataya H, Mak RH, Honda M. Posterior reversible encephalopathy syndrome in children with kidney diseases. Pediatr Nephrol. 2012;27(3):375-84.
Onder AM, Lopez R, Teomete U, Francoeur D, Bhatia R, Knowbi O, et al. Posterior reversible encephalopathy syndrome in the pediatric renal population. Pediatr Nephrol. 2007;22(11):1921-9.
Jones BV, Egelhoff JC, Patterson RJ. Hypertensive encephalopathy in children. AJNR Am J Neuroradiol. 1997;18(1):101-6.