Co-existence of multisystem inflammatory syndrome in children associated with COVID-19 and scrub typhus infection: a case series

Authors

  • Sarbani M. Roy Department of Pediatric Medicine, Malda Medical College and Hospital, Malda Town, West Bengal, India
  • Sushama Sahoo Department of Pediatric Medicine, Malda Medical College and Hospital, Malda Town, West Bengal, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20214847

Keywords:

MIS-C, Kawasaki disease, Scrub typhus, Concomitant infection, SARS-CoV-2

Abstract

We are in the midst of pandemic of corona virus disease (COVID-19), caused by the novel coronavirus severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). A clinical entity with hyperinflammatory syndrome, defined by World Health Organization (WHO) as multisystem inflammatory syndrome in children (MIS-C) and adolescents, temporarily related to COVID-19, is being reported in this pandemic from several countries. MIS-C has overlapping clinical features of Kawasaki disease (KD). KD has been described in association with various organisms including dengue, scrub typhus. MIS-C with concomitant infection has rarely been reported in literature till date. We report on ten sick pediatric patients presented with clinical features of MIS-C, in whom diagnosis of concomitant scrub typhus were also made. This retrospective study was conducted in the department of pediatric medicine of a medical college, in a district town of West Bengal, India. SARS-CoV-2 immunoglobulin G level was elevated in all of them and they were also positive with Scrub typhus serology. We reviewed and analysed their basic informations, clinical manifestations, epidemiological history, laboratory findings, treatment and short term outcome. Median age was 24 months (range 4 months-8 years), male: female was 1:1. All the patients survived. Concomitant tropical infection in a patient with MIS-C may play an important role in determining the prognosis of such patients. Early detection and intervention will result in better management and intact survival of them.

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Author Biography

Sarbani M. Roy, Department of Pediatric Medicine, Malda Medical College and Hospital, Malda Town, West Bengal, India

Associate Professor, Department of Pediatric Medicine, Malda Medical College and Hospital, Malda Town, West Bengal,India.

References

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Verdoni L, Mazza A, Gervasoni A. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: An observational cohort study. Lancet. 2020;395:1771-8.

Royal College of Pediatrics and Child Health. Guidance– Pediatric multisystem inflammatory syndrome temporally associated with COVID-19, 2020. Available at: https:// www.rcpch.ac.uk/ resources/guidance-pediatric-multisystem-inflammatory-syndrome-temporally-associated covid-19. Accessed on 05 May 2020.

Gupta A, Gill A, Sharma M, Garg M. Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease. J Trop Pediatr. 2021;67(3):fmaa060.

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Published

2021-12-24

How to Cite

Roy, S. M., & Sahoo, S. (2021). Co-existence of multisystem inflammatory syndrome in children associated with COVID-19 and scrub typhus infection: a case series. International Journal of Contemporary Pediatrics, 9(1), 112–115. https://doi.org/10.18203/2349-3291.ijcp20214847

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Section

Case Series