An epidemiological study on the clinico-hematological profile of pediatric patients with congenital hemolytic anemia

Santosh Kumar, Deepa Singh, Abhay Garg


Background: Among the inherited disorders of blood, haemoglobinopathy and thalassaemia constitute a major bulk of congenital hemolytic anemia in India.

Methods: The present cross sectional study was conducted on pediatric patients aged 0-15 years admitted in pediatric ward of Department of Pediatrics, MGM Medical College and LSK Hospital, Kishanganj, Bihar, India between December 2015 to November, 2016. The data on socio-demographic profile, relevant clinical history and examination and hematological parameters were assessed.

Results: Out of 211 patients evaluated, most common cause of congenital hemolytic anemia was Hb E Beta thalassemia (39.8%), followed by beta thalassemia (27.9%), beta thalassemia trait (14.2%), Hb E disease (11.3 %) and Hb E trait (6.6%). There was male preponderance (male 63%, female 37 %). The mean hemoglobin was found to be lowest in patients of β thalassemia (5.1 gm/gl) and HbE β thalassemia (5.8 gm/dl). The mean total serum bilirubin was found to be highest among β Thalassemia patients (3.0 mg/dl). Hepatomegaly was the most common clinical finding among the study population (57.8%), followed by splenomegaly (54.9%) and hemolytic facies and jaundice (both 53%).

Conclusions: The incidence of HbE beta thalassemia is relatively high in comparison to other varieties of thalassemias and is a major public health problem in this area of the country.


Beta thalassemia, Congenital hemolytic anemia, Hb E beta thalassemia

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