Chronic idiopathic thrombocytopenic purpura in a child with Sanfilippo type A


  • Karthik Prabhu Ramaraj Department of Pediatrics, Kanchi Kamakoti Childs Trust Hospital, Chennai, Tamil Nadu, India
  • Suresh Natarajan Department of Pediatrics, Kanchi Kamakoti Childs Trust Hospital, Chennai, Tamil Nadu, India
  • Ravikumar KG Department of Pediatrics, Kanchi Kamakoti Childs Trust Hospital, Chennai, Tamil Nadu, India



MPS, Sanfilippo type A, Idiopathic thrombocytopenic purpura


Mucopolysaccharidoses (MPS) are a group of storage disorders with an autosomal recessive inheritance. Sanfilippo disease is a type of MPS which occurs due to deficiency of lysosomal enzymes involved in the lysosomal degradation of heparan sulphate. They can be categorized into four different types based on the enzymes involved namely heparin N-sulfatase (type A), alpha-N-acetylglucosaminidase (type B), acetyl-CoA-glucosaminide acetyltransferase (type C) and N-acetylglucosamine-6-sulfatase (type D) respectively. In this case report we present a six years follow up of a child confirmed to have Sanfilippo type A disease, who developed chronic Idiopathic Thrombocytopenic Purpura (ITP).


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