A prospective study of analysis of Cord blood gas to predict the  short term outcome in high-risk deliveries

Ramisetty Uma Mahesh; Vishnu Vandana Matli

doi:10.18203/2349-3291.ijcp20214094

Authors

Ramisetty Uma Mahesh Department of Pediatrics, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India
Vishnu Vandana Matli Department of Pediatrics, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20214094

Keywords:

Cord blood gas pH, Resuscitation, Convulsions, Encephalopathy

Abstract

Background: Neonatal acidaemia at birth will increase the neonatal morbidity and mortality. It is a predictive marker of neonatal asphyxia. The current study aimed to investigate the relationship between cord blood gas analysis and neonatal outcome.

Methods: A prospective hospital based observational study conducted in 150 term newborns. Cord Blood gas levels were examined, pH of 7.25 was observed in 70 samples. The primary outcomes measured were the percentage of NICU admission, need for resuscitation, convulsions, and encephalopathy.

Results: Primary outcome of NICU admission, need for resuscitation, and delay in attaining full feeds were observed to have statistical significance. The majority of the babies had pH levels that were within the normal range and had a healthy outcome. NICU admission and the need for resuscitation were observed in babies from group with acidic pH (<7.25).

Conclusions: Cord blood analysis had prognostic significance in predicting outcomes in the new-born period.

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References

Watterberg KL, Aucott S, Benitz WE, Cummings JJ, Eichenwald EC, Goldsmith J et al. The Apgar score. Pediatrics. 2015;136(4):819-22.

Ehrenstein V. Association of Apgar scores with death and neurologic disability. Clin Epidemiol. 2009;1:45-53.

Tataranno M, De Bernardo G, Trevisanuto D, Sordino D, Riccitelli M, Buonocore G et al. Differences between umbilical blood gas in term and preterm newborns. Electron Physician. 2019;11(2):7529-35.

Pramod S, Gunchan P, Sandeep P. Interpretation of arterial blood gas. Indian J Crit Care Med. 2010;14(2):57-64.

Martin O, Sarah J, Sailesh K. Respiratory distress of the term newborn infant. Paediatr Respir Rev. 2013;14:29-37.

William A, Silverman D, Andersen A. Controlled clinical trial of effects of water mist on obstructive respiratory signs, death rate and necropsy findings among premature infants. Pediatrics. 1956;17(1):1-10.

Sabol B, Caughey A. Acidemia in neonates with a 5-minute Apgar score of 7 or greater - What are the outcomes? Am J Obstet Gynecol. 2016;215(4):486.e1-6.

Hermansen M. The acidosis paradox: asphyxial brain injury without coincident acidemia. Dev Med Child Neurol. 2003;45(5):353-6.

Martí GS, Pascual MJ, Rodrigo RM, Ruiz SJ, Castán MS. pH, base deficit or lactate. Which is better for predicting neonatal morbidity? J Matern Fetal Neonatal Med. 2017;30(19):2367-71.

Kacho MA, Zahedpasha Y, Hagshenas M. Short outcome of neonates born with abnormal umbilical cord arterial blood gases. Iran J Pediatr. 2015.25(3):e174.

Rogers KA, Ramalingam K. Correlation between umbilical arterial pH<7.12 & early neonatal outcomes. Arch Dis Child Fetal Neonatal. 2014;5(2):20-4.

Malin GL, Morris RK, Khan KS. Strenghth of associat ion between umbil ical cord pH & long term outcomes : systemat ic review and meta -analysis. BMJ. 2010;340:c1471.

Goodwin TM, Belai I, Hernandez P, Durand M, Paul RH. Asphyxial complications in the term newborn with severe umbilical acidemia. American journal of obstetrics and gynecology. 1992;167(6):1506-12.

Knutzen L, Aye C, Anderson‐Knight H, Svirko E, Impey L. Arteriovenous differences in cord blood gas analysis and the prediction of adverse neonatal outcome. Acta obstetricia et gynecologica Scandinavica. 2018;97(6):688-93.