Usage of antibiotics and monitoring of drug interactions in pediatrics at a tertiary care teaching hospital

Authors

  • Rajasekar N. Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India
  • Kireesh Kumar M. Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India
  • Sowndarya M. Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India
  • Dhanapal C. K. Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India
  • Ramanathan R. Department of Pediatrics, Rajah Muthaiah Medical College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20214154

Keywords:

Antibiotics, Children, Respiratory tract infection, Cephalosporin

Abstract

Background: Respiratory tract infections (RTI) are more common in pediatrics. Especially in developing countries like India, RTI causes more death in children. Antibiotics are used to treat RTI even in case of viral infections. Hence rational use of antibiotics is very much needed to avoid antibiotic resistance. In this study we have analysed the prescribing pattern of antibiotics and their drug interactions involved in the management of respiratory tract infections in a tertiary care teaching hospital.

Methods: A prospective observational study was conducted in the department of pediatrics at a tertiary care teaching hospital for a period of 6 months (November 2019-April 2020). A total of 144 patients were included in the study and their prescription was analysed for their antibiotic prescribing pattern and interactions.

Results: Infants were more prone to RTI infections. Among RTI, lower RTI were more common in children. We have analysed prescribing pattern of antibiotics in which, mono antibiotic therapy were more commonly used. Ampicillin was the frequently prescribed antibiotic. Azithromycin had the most possible interactions among the antibiotics prescribed.

Conclusions: More than 336 antibiotics were used for all types of RTI, even in the case of viral infections. So rational use of antibiotics is needed. Among 144 children who were enrolled in the study, none of them were subjected to culture sensitivity test. As of which, all of them were treated empirically. Penicillin and cephalosporin are the mostly prescribed antibiotics in RTI. Cephalosporin prescribed children had less hospital stay and hardly interactions were found.

References

Center. International Journal of Recent Scientific Research. Center. Int J Rec Sci Res. 2015;6(6):4558-63.

Bryce A, Hay AD, Lane IF, Thornton HV, Wootton M, Costelloe E. BMJ. 2016;352:939.

Sai MVS, Divya K, Devi G, Sharma S. A study on prescribing pattern of antibiotics in respiratory tract infections in a tertiary care. Int J Sci Res. 2018;6(6).

Chandra S, Mayank K, Shaifali I, Ranjan R. Prescription analysis based on the World Health Organization core prescribing indicators in pediatric population having respiratory tract infections. Natl J Physiol Pharm Pharmacol. 2019;9(8):784-7.

Tobia CC, Aspinall SL, Good CB, Fine MJ. Appropriateness of antibiotic prescribing veterans with community– acquired pneumonia, sinusitis or acute exacerbation of bronchitis: a cross- sectional study. Clin Therap. 2008;30(6):1135-44.

Everard ML. Pediatric respiratory infections. Eur Respirator J Rev. 2016;25:36-40.

Naik HG, Khanwelkar CC, Kolur A, Desai R, Gidamudi S. Drug utilization study on antibiotics use in the upper respiratory tract infection. International journal of recent trends in science and technology. Int J Res Trend Sci Tech. 2014;10(2):299-302.

Gairola B, Choudhury D, Phukan D, Deka A. Drug prescribing pattern in respiratory tract infection in children aged 1 to 12 years. J Pharm Biomed Sci. 2016;6(10):537-45.

Choudhury DK, Bezbaruah BK. Antibiotic prescriptions pattern in paediatric in-patient department Gauhati medical college and hospital, Guwahati. J App Pharm Sci. 2013;3(08):144-8.

Badar V, Parulekar V, Garate P. A prescription pattern study of respiratory tract infection in pediatric indoor patients in tertiary care teaching hospital. Asian J Pharm Clin Res. 2018;11(7).

Malladi P, Hasna AH, Ramesh S, Manna PK. Role of clinical pharmacist in promoting rational use of antimicrobial in the management of pediatric lower respiratory tract infection in a tertiary care teaching hospital. IJRPC. 2012;2(2):360-70.

Naik HG, Khanwelkar CC, Kolur A, Desai R, Gidamudi S. Drug utilization study on antibiotics use in respiratory tract infection. NJMR. 2013;3(4):324-7.

Woodhead M, Blasi F, Ewig S, Garau J, Huchon G, Ieven M, et al. Guidelines for the management of adult lower respiratory tract infections. Clin Microbiol Infect. 2011;17(6):1-59.

Everard ML. Paediatric respiratory infections. Eur Respir Rev. 2016;25(139):36-40.

Akbari N, Prudhivi R, Naidu S. Rational use of antibiotics and monitoring of drug interactions in patients with respiratory tract infection. J Pharm Pract Community Med. 2018;4(4):211-5.

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Published

2021-10-25

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Original Research Articles