Published: 2021-10-25

A study on impact of iron deficiency on cognition and anthropometry in pediatrics and clinical pharmacist’s intercession to provide awareness about iron deficiency in tertiary care teaching hospital

Aishvarya V., Roshine P., Elayarani M., Mahendravarman P., Saravanan S.


Background: Micronutrient deficiencies largely affect pediatric population worldwide. In India, pediatric category is more prone to iron deficiency, the most common micronutrient deficiency disorder which produces haematological as well as non-hematological disturbances. This study aimed to identify the impact of iron deficiency on cognitive function and anthropometric changes in pediatric populations.

Methods: A hospital based, prospective observational study was conducted at Department of Pediatrics in Rajah Muthiah Medical College and Hospital, 127 participants were enrolled in this study. BKT kit of Intelligence, Electronic weighing machine, Stadiometer, BMI Calculator by CDC guidelines and patient’s haemoglobin values were used in this study.

Results: Out of 127 patients, 66 patients had iron deficiency with anemia and remaining 61 had iron deficiency without anemia. Cognitive behaviour was assessed based on the norms and majority were under the category- dull average (52 patients) followed by average (45 patients) and other’s had single digit patients. Growth charts of Indian Academy of Pediatrics were used to assess anthropometric characteristics and majority were in the underweight category (61.4%) followed by average category (38.6 %).

Conclusions: Low cognitive scores and underweight were found in participants with low haemoglobin levels. Hence, our study provides convincing evidence that iron plays a vital role in the cognition, motor and physical growth. Awareness about the importance of iron and the health issues associated with its deficiency was also provided to the participants.


Iron deficiency, Cognition, Binet – kamat test, Anthropometry, CDC BMI calculator, WHO – IAP combined chart, Awareness

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Iron and iron deficiency. U.S. Centers for Disease Control and Prevention. Available at: Accessed on 11 September 2013.

Nutrition and iron deficiency anemia. Available at: Accessed on 11 September 2013.

Hermoso M, Vucic V, Vollhardt C, Arsic A, Roman-Viñas B, Iglesia-Altaba I et al. The Effect of Iron on Cognitive Development and Function in Infants, Children and Adolescents: A Systematic Review. Ann Nutr Metab. 2011;59:154-65.

Naseem A, Khan SA, Lalani N. Impact of iron deficiency on cognitive functions and effect of iron supplement in children between 5-10 years: Indian perspective. Int J of Pediatric Research. 2016;3(5).

Hioui M, Ahami AOT, Aboussaleh Y, Azzaoui FZ, Rusinek S. Effect of Iron-Deficiency on Cognitive Skills and Neuromaturation in Infancy and Childhood. Science International. 2015;3(3):85-9.

Lozoff B, Brittenham GM. Behavioral alterations in iron deficiency. Hematol Oncol Clin North Am. 1987;1(3):449-64.

Walter T. Effect of iron-deficiency anemia on cognitive skills and neuromaturation in infancy and childhood. Food Nutr Bull. 2003;24(4):S104-10.

More S, Shivkumar VB, Gangane N, Sumeet Shende, Effects of Iron Deficiency on Cognitive Function in School Going Adolescent Females in Rural Area of Central India, Hindawi Publishing Corporation. 2013;819136.

McGregor SG, Ani C. A Review of Studies on the Effect of Iron Deficiency on Cognitive Development in Children. American Society for Nutritional Sciences. 0022-3166/01

Pollitt E. In: Effects of iron deficiency on mental development: Methodological considerations and substantial findings. Johnston FE, ed. Nutr Anthropol. New York: Liss. 1987;225-54.

Jáuregui-Lobera I. Iron deficiency and cognitive functions. Dove. 2014;10:2087-95.

Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131:649S-68S.

Iron Deficiency Anaemia: Assessment, Prevention and Control: A guide for programme managers, Geneva. World Health Organization. WHO. Available at: Accessed on 10 August 2021.

WHO. Preventing and controlling anaemia through primary health care: a guide for health administrators and program managers. Geneva. World Health Organization. 1989. Available at: Accessed on 10 August 2021.

Kliegman RM, Geme JS, Blum, Shah, Tasker, Wilson. Nelson textbook of pediatrics. 21st ed. Elsevier.

Madan N, Rusia U, Sikka M, Sharma S, Shankar N. Developmental and neurophysiologic deficits in iron deficiency in children. Indian J Pediatr. 2011;78(1):58-64.

Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007;28(4):S560-71.

Ibrahim A, Atef A, Magdy RI, Farag MA. Iron therapy and anthropometry: A case-control study among iron deficient preschool children. Elsevier. The Egyptian Pediatric Association. 2017;65:95-100.

Ghali I, Salah N, Hussien F, Erfan M, El-Ruby M, Mazen I, et al. Egyptian growth curves for infants, children and adolescents. Crecere nel mondo. Satorio A, Buckler JMH and Marazzi N, Eds. Ferring Publisher, Milan, Italy. 2008.

Perg W, Mora Plazas M, Marti C, Villamor E. iron status and linear growth: a prospective study in school-age children. Eur J clin nutr. 2013;67:646-51.

Carter RC, Jacobson SW, Molteno CD, Jacobson JL. Iron deficiency anemia and infant growth. Pediatrics. 2007;11:159-67.

Body Mass Index calculator for teens and kids. Available at: /bmi/calculator.html. Accessed on 11 September 2020.