Multisystem inflammatory syndrome in children associated with 2019 novel coronavirus (SARS-CoV-2) infection

Authors

  • Arungeethan Arunanandh Department of Pediatrics, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, India
  • Mohanram . Department of Pediatrics, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, India
  • Antony J. Department of Pediatrics, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20220767

Keywords:

Multisystem inflammatory syndrome in children, SARS CoV- 2, COVID-19

Abstract

Being in the middle of a global pandemic of coronavirus disease (COVID-19), caused by the novel coronavirus SARS-CoV-2 there were never ending speculation regarding the occurrence, causation, spread and treatment of the disease which warranted a never ending research on this aspect. Initially was thought to be affecting children with lesser severity, but now it has been observed that, SARS-CoV-2 infection has recently been associated with a novel set of clinical manifestations presently called multisystem inflammatory syndrome in children (MIS-C) which was recognised at the outset by the United States, which lacked published reports by then. Here, we describe three critically ill patients with the spectrum of MIS-C associated with SARS CoV- 2 infection presenting to a tertiary-care center in India. Clinical presentation of MIS-C with multi-organ involvement and elevated inflammatory markers may have a presentation which is similar to the presentation as seen in Kawasaki disease and toxic shock syndrome. But now it has been presently understood to be a separate phenomenon and it has been related to a post-viral immune-mediated inflammatory process, and the pathogenesis of the occurrence of this syndrome complex still remains unclear.

Author Biographies

Arungeethan Arunanandh, Department of Pediatrics, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, India

DEPARTMENT OF PEDIATRICS

CHETTINAD HOSPITAL AND RESEARCH INSTITUTE

Mohanram ., Department of Pediatrics, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, India

Consultant

Department of pediatrics

Antony J., Department of Pediatrics, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, India

Professor

Department of pediatrics

References

Nunez-Martinez PM, Garcia-Delgado C, Moran-Barroso VF, Jasso-Gutierrez L. Congenital macroglossia: clinical features and therapeutic strategies in paediatric patients. Bol Med Hosp Infant Mex. 2016;73(3):212-6.

Topouzelis N, Iliopoulos C, Kolokitha OE. Macroglossia. Int Dent J. 2011;61(2):63-9.

Prada CE, Zarate YA, Hopkin RJ. Genetic causes of macroglossia: diagnostic approach. Pediatrics. 2012;129(2):431-7.

Kagan KO, Berg C, Dufke A, Geipel A, Hoopmann M, Abele H. Novel fetal and maternal sonographic findings in confirmed cases of Beckwith-Wiedemann syndrome. Prenat Diagn. 2015;35(4):394-9.

Dudhia SB, Dudhia BB. Undetected hypothyroidism: a rare dental diagnosis. J Oral Maxillofac Pathol. 2014;18(2):315-9.

Heggie AA, Vujcich NJ, Portnof JE, Morgan AT. Tongue reduction for macroglossia in Beckwith Wiedemann syndrome: review and application of new technique. Int J Oral Maxillofac Surg. 2013;42(2):185-91.

Downloads

Published

2022-03-24

Issue

Section

Case Series