Published: 2021-08-23

Neonatal aspergillus endocarditis: case report and review of literature

Amrita Roy, Debadatta Mukhopadhyay, Tamashis Mukherjee, Kaustabh Chaudhuri


Neonatal fungal endocarditis (FE) remains a rare condition associated with prematurity. It often puts us in diagnostic and therapeutic dilemma as there are no specific guidelines. We described our successful journey with a 26 days old neonate with aspergillus endocarditis responding to multidisciplinary approach with surgical resection and intravenous antifungals.



Fungal, Endocarditis, Aspergillus, Surgical resection

Full Text:



Millar BC, Jugo J, Moore JE. Fungal endocarditis in neonates and children. Pediatr Cardiol. 2005;26(5):517-36.

Yuan SM. Fungal Endocarditis. Braz J Cardiovasc Surg. 2016;31(3):252-5.

Humpl T, McCrindle BW, Smallhorn JF. The relative roles of trans-thoracic compared with trans-esophageal echocardiography in children with suspected infective endocarditis. J Am Coll Cardiol. 2003;41(11):2068-71.

Ganesan V, Ponnusamy SS, Sundaramurthy R. Fungal endocarditis in paediatrics: a review of 192 cases (1971-2016). Cardiol Young. 2017;27(8):1481-7.

Shane AL, Stoll BJ. Recent developments and current issues in the epidemiology, diagnosis, and management of bacterial and fungal neonatal sepsis. Am J Perinatol. 2013;30(2):131-41.

Pana ZD, Dotis J, Iosifidis E, Roilides E. Fungal endocarditis in neonates: a review of 71 cases (1971-2003). Pediat Infect Dis J. 2015;34(8):803-8.

Pappas PG, Kauffman CA, Andes D, Benjamin DK, Calandra TF, Edwards JE, et al. Infectious diseases society of America. Clinical practice guidelines for the management of candidiasis: 2009 update by the infectious diseases society of America. Clin Infect Dis. 2009;48(5):503-35.

Cornely OA, Bassetti M, Calandra T, Garbino J, Kullberg BJ, Lortholary O, et al. ESCMID fungal infection study group. ESCMID guideline for the diagnosis and management of candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect. 2012;18(7):19-37.

Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, et al. Treatment of aspergillosis: clinical practice guidelines of the infectious diseases society of America. Clin Infect Dis. 2008;46(3):327-60.

Nomura F, Penny DJ, Menahem S, Pawade A, Karl TR. Surgical intervention for infective endocarditis in infancy and childhood. Ann Thorac Surg. 1995;60(1):90-5.