Serum zinc levels in children with simple febrile seizures

Karthikeyan Pannerselvam, Prasanna Raju, Sathyamoorthy Mani, Sowjan Manohar Reddy, P. Sekar


Background: Febrile convulsions are the most common type of seizures in children. Febrile seizure is an event in infancy and early childhood usually occurring between 6 months and 5 years of age, associated with fever but without the evidence of intracranial infection or defined cause. Febrile convulsions have good prognosis. Zinc acts as a cofactor of glutamic acid decarboxylase, an enzyme which maintains the production of GABA in central nervous system. The aim of the present prospective observational study was to estimate the levels of serum zinc in children with febrile convulsions and to compare serum zinc levels between children with febrile seizures and febrile children without seizures.

Methods: A prospective observational study was done on 100 children for one year period from August 2012 to July 2013, admitted in a tertiary care centre. Of these 50 children were diagnosed to have febrile convulsions. The other 50 were febrile children without seizures. Serum zinc levels were measured in all 100 subjects using calorimetric methods. Data was analyzed using SPSS version 15.

Results:Mean serum zinc levels in children with febrile seizures were 68.4 micrograms/decilitre and mean serum zinc levels in control group was 94.1 micrograms/dl (p=0.0001). There were no significant differences in relation to age and gender. Serum zinc levels were significantly low in children who had febrile seizures of prolonged duration (p=0.0001).

Conclusions: These findings revealed that there is correlation between serum zinc and simple febrile seizures. Serum zinc level was significantly lower in children with simple febrile seizures in comparison with febrile children without seizure.


Simple febrile seizures, Serum zinc

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