DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20150988

Serum zinc levels in children with simple febrile seizures

Karthikeyan Pannerselvam, Prasanna Raju, Sathyamoorthy Mani, Sowjan Manohar Reddy, P. Sekar

Abstract


Background: Febrile convulsions are the most common type of seizures in children. Febrile seizure is an event in infancy and early childhood usually occurring between 6 months and 5 years of age, associated with fever but without the evidence of intracranial infection or defined cause. Febrile convulsions have good prognosis. Zinc acts as a cofactor of glutamic acid decarboxylase, an enzyme which maintains the production of GABA in central nervous system. The aim of the present prospective observational study was to estimate the levels of serum zinc in children with febrile convulsions and to compare serum zinc levels between children with febrile seizures and febrile children without seizures.

Methods: A prospective observational study was done on 100 children for one year period from August 2012 to July 2013, admitted in a tertiary care centre. Of these 50 children were diagnosed to have febrile convulsions. The other 50 were febrile children without seizures. Serum zinc levels were measured in all 100 subjects using calorimetric methods. Data was analyzed using SPSS version 15.

Results:Mean serum zinc levels in children with febrile seizures were 68.4 micrograms/decilitre and mean serum zinc levels in control group was 94.1 micrograms/dl (p=0.0001). There were no significant differences in relation to age and gender. Serum zinc levels were significantly low in children who had febrile seizures of prolonged duration (p=0.0001).

Conclusions: These findings revealed that there is correlation between serum zinc and simple febrile seizures. Serum zinc level was significantly lower in children with simple febrile seizures in comparison with febrile children without seizure.


Keywords


Simple febrile seizures, Serum zinc

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References


World Health Organization. Atlas: epilepsy care in the world. Geneva: World Health Organization; 2005: 91.

World Health Organization. “Epilepsy” fact sheets, October 2012. Available at: http://www.who.int/mediacentre/factsheets/fs999/en/. Accessed 24 January 2013.

Kleigman RM, Stanton BF, Schor NF, St. Geme JW, Bherman RE. Chapter 586. In: Kleigman RM, Stanton BF, Schor NF, St. Geme JW, Bherman RE, eds. Nelson Textbook of Pediatric. 19th ed. Philadelphia: Saunders; 2012: 2017.

Doose H, Maurer A. Seizure risk in offspring of individuals with a history of febrile convulsion. Eur J Pediatr. 1997;156:476-81.

Prasad AS. Zinc deficiency: has been known of for 40 years but ignored by global health organisations. Br Med J. 2003;326(7386):409-10.

Broadley MR, White PJ, Hammond JP, Zelko I, Lux A. Zinc in plants. N Phytol. 2007;173:677-702.

7. Hambidge KM, Krebs NF. Zinc deficiency: a special challenge. J Nutr 2007; 137(4):1101-5.

Nakashima AS, Dyck RH. Zinc and cortical plasticity. Brain Res Rev. 2009;59(2):347-73.

Mollah MA, Dey PR, Tarafdar SA, Akhter S, Ahmed S, Hassan T, et al. Zinc in CSF of patients with febrile convulsion. Indian J Pediatr. 2002;69(10):859-61.

Mishra OP, Singhal D, Upadhya RS, Prasad R, Atri D. Cerebrospinal fluid zinc, magnesium, copper and gammaaminobutyric acid levels in febrile seizure. J Pediatr Neurol. 2007;5:39-44.

Frederickson CJ, Suh SW, Silva D, Frederickson CJ, Thompson RB. Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr. 2000;130(5S Suppl):1471S-83S.

Ebadi M, Pfeiffer RF. Zinc in neurological disorders experimentally induced epileptiform seizures. In: Frederickson CJ, Howell GA, Kasarskis EJ, eds. The Neurobiology of Zinc. Vitamin B6 Deficiency. Toxicity and Pathology. 2nd ed. New York: Alan R Liss Inc; 1984: 307-324.

Ganesh R, Janakiraman L. Serum zinc levels in children with simple febrile seizures. Clin Pediatr. 2008;47:164-6.

Kumari PL, Nair MKC, Nair SM, Lalitha K, Geetha S. Iron deficiency as a risk factor for simple febrile seizures - a case control study. 2001 May;30(5):1-4.

Hartifeld DS, Tan J, Yager JY, Rosychuk RJ, Spandy D, Haines C, et al The association between iron deficiency and febrile seizure in childhood. Clin Pediatr. 2009;48(4):420-6.

Guzman AR, Castillejos EL, Vicuña WL, Laguia VL, Balarezo W, Gurreoner RL. Anemia: a possible risk factor for the first febrile seizure. Paediatrica. 2005;7(2):62-5.

Offringa M, Bossuyt PM, Lunsen J, Ellenberg JH, Nelson KB, Kundsen FU, et al. Risk factors of seizures recurrences in children with febrile seizures: a polled analysis of individual patient data form studies. J Pediatr. 1994;124:574-8.

Sadlier LG, Scheffer IE. Febrile seizures. BMJ. 2007;334:307-11.

Berg AT, Shinnar S. Unprovoked seizures in children with febrile seizures: short-term outcome. Neurology. 1996;47:562-8.

Papierkowski A, Mroczkowska-Juckiewicz A, Pawlowska-Kamieniak A, Pasternak K. Magnesium and zinc levels in blood serum and cerebrospinal fluid in children with febrile convulsions. Pol Merkur Lekarski. 1999;6(33):138-40.

Hershfinkel, Silverman M, William F, Sekler, Israel. The zinc sensing receptor, a link between zinc and cell signaling. Molecul Med. 2007;13(7-8): 331-6.

Kumar L, Chaurasiya OS, Gupta AH. Prospective study of level of serum zinc in patients of febrile seizures, idiopathic epilepsy and CNS infections. People’s J Sci Res. 2011;4:1-4.

Ehsanipour F, Talebi-Taher M, Harandi N, Kani K. Serum zinc level in children with febrile convulsion and its comparison with that of control group. Iran J Pediatr. 2009;199:65-8.

Amiri M, Farzin L, Moassessi ME, Sajadi F. Serum trace element levels in febrile convulsion. Biol Trace Elem Res. 2010;135(1-3):38-44.

Mahyar A. The preventive role of zinc from communicable and noncommunicable diseases in children. NCD Malaysia. 2005;4:21-5.

Margharetha L, Masloam N. Correlation between serum zinc levels and simple febrile seizure in children. Pediatr Indonesia. 2010;50:326-30.