Granulomatous vulvitis and Gullain-Barre syndrome in pediatric Crohn’s disease: a case report
DOI:
https://doi.org/10.18203/2349-3291.ijcp20212061Keywords:
Crohn’s, Inflammatory bowel disease, Granulomatous vulvitis, Guillain Barre syndromeAbstract
Granulomatous vulvitis/cheilitis may occur rarely as an extraintestinal manifestation of Crohn’s disease (CD) and may precede the development of gastrointestinal symptoms. Guillain-Barre syndrome (GBS) is associated with a wide variety of illnesses including inflammatory bowel disease. Though the immunologic abnormalities in inflammatory bowel disease may encompass both granulomatous inflammation as well as autoimmune components, the combination of CD, GBS and granulomatous vulvitis/cheilitis in the same patient has not been described in literature. We hereby reported a 14 year old girl with granulomatous vulvitis/cheilitis for 4 years preceding the development of gastrointestinal manifestations of CD, who also had GBS during the course of hospitalization.References
Kapoor A, Bhatia V, Sibal A. Pediatric inflammatory bowel disease. Indian Pediatr. 2016;53(11):993-1002.
Nabatian AS, Shah KN, Iofel E, Rosenberg S, Javidian P, Pappert A, et al. Asymptomatic granulomatous vulvitis and granulomatous cheilitis in childhood: the need for Crohn disease workup. J Pediatr Gastroenterol Nutr. 2011;53(1):100-1.
McCallum DI, Gray WM. Metastatic Crohn’s disease. Br J Dermatol. 1976;95(5):551-4.
Vaid RM, Cohen BA. Cutaneous CD in the pediatric population. Pediatr Dermatol. 2010;27:279-81.
Marks DJ, Miyagi K, Rahman FZ, Novelli M, Bloom SL, Segal AW. Inflammatory bowel disease in CGD reproduces the clinicopathological features of CD. Am J Gastroenterol. 2009;104(1):117-24.
Yanagida H, Sugimoto K, Izu A, Wada N, Sakata N, Takemura T. Guillain-Barré syndrome and Crohn disease: a case report. J Child Neurol. 2014;29(9):78-80.
Fuente-Fernández R, Rubio-Nazabal E, Iglesia-Martínez F. Guillain-Barré syndrome as an extraintestinal manifestation of CD. Postgrad Med J. 1995;71(837):437-8.
García-Cabo C, Morís G. Peripheral neuropathy: an underreported neurologic manifestation of inflammatory bowel disease. European J Internal Med. 2015;26(7):468-75.
Cárdenas-Roldán J, Rojas-Villarraga A, Anaya JM. How do autoimmune diseases cluster in families? A systematic review and meta-analysis. BMC Med. 2013;11:73.
Forabosco P, Bouzigon E, Ng MY, Hermanowski J, Fisher SA, Criswell LA, et al. Meta-analysis of genomewide linkage studies across autoimmune diseases. Eur J Hum Genet. 2009;17(2):236-43.
Wilson JC, Furlano RI, Jick SS, Meier CR. Inflammatory bowel disease and the risk of autoimmune diseases. J Crohns Colitis. 2016;10(2):186-93.
