COVID-19 and multi-system inflammatory syndrome in children: keep a high index of suspicion in all inflammatory disorders
Keywords:COVID-19, MIS-C, Kawasaki disease, Transverse myelitis, Intravenous immunoglobulins
COVID-19 pandemic put many challenges for the health care professionals and one of that is the multi-system inflammatory syndrome in children (MIS-C). This syndrome shares its features with other inflammatory conditions including Kawasaki disease and toxic shock syndrome. We are reporting 4 cases from a tertiary care center in COVID-19 hotspot area in the state of Uttar Pradesh who presented with multiple organ system involvement.
Shah SK, Munoz AC. Multisystem Inflammatory Syndrome in Children in COVID-19 Pandemic. Indian J Pediatr. 2020;87(9):671-3.
Rauf A, Vijayan A, John ST, Krishnan R, Latheef A. Multisystem Inflammatory Syndrome with Features of Atypical Kawasaki Disease during COVID-19 Pandemic. Indian J Pediatr. 2020;87(9):745-7.
World Health Organization (WHO) Multisystem inflammatory syndrome in children and adolescents with COVID-19. Available at: https://www.who. int/publications-detail/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19. Accessed on 11 May 2020
Godfred-Cato S, Bryant B, Leung J. COVID-19-Associated Multisystem Inflammatory Syndrome in Children-United States, March-July 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1074-80.
Esper F, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Association between a novel human coronavirus and Kawasaki disease. J Infect Dis. 2005;191(4):499-502.
Katzelnick LC, Gresh L, Halloran ME. Antibody-dependent enhancement of severe dengue disease in humans. Science. 2017;358(6365):929-32.
Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P et al. PIMS-TS Study Group and EUCLIDS and PERFORM Consortia. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. 2020;324:259-69.
Curtis M, Bhumbra S, Felker MV. Guillain-Barré syndrome in a child with COVID-19 infection. Pediatrics. 2020;e2020015115.
Rahimi, K. Guillain-Barre syndrome during COVID-19 pandemic: an overview of the reports. Neurol Sci. 2020;41:3149-56.
Abdelhady M, Elsotouhy A, Vattoth S. Acute flaccid myelitis in COVID-19: a case report BJR Case Rep. 2020;6:3.