Pathogenesis of COVID-19 and multi-system inflammatory syndrome in children

Authors

  • Arundhathi Shankaralingappa Department of Pathology, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India
  • Arun Babu Thirunavukkarasu Department of Pediatrics, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India http://orcid.org/0000-0003-1123-5270

DOI:

https://doi.org/10.18203/2349-3291.ijcp20211096

Keywords:

COVID-19, SARS CoV-2, Multi-system inflammatory syndrome in children, Pathogenesis, Children

Abstract

World health organization declared COVID-19 caused by SARS CoV-2 virus as a pandemic in early 2020. The target cells facilitating viral entry are ACE-2 receptor bearing cells like bronchial epithelial cells and pneumocytes.  Children pose a less risk compared to adults in acquiring this disease and mortality in them is low due to protective pathogenesis. Children with COVID-19 are also at risk of developing unique immunological phenomena, known as multi-system inflammatory syndrome in children. MIS-C is considered to be hyperimmune state resulting from cytokine storm and circulating immune complexes. This mini-review reflects the most recent understanding of the pathogenesis in children with special emphasis on MIS-C.

Author Biographies

Arundhathi Shankaralingappa, Department of Pathology, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India

Associate Professor,

Dept of Pathology,

All India Institute of Medical Sciences (AIIMS), Mangalagiri

Andhra Pradesh, India

Arun Babu Thirunavukkarasu, Department of Pediatrics, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India

Associate Professor of Pediatrics AIIMS, Mangalagiri

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Published

2021-03-23

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Section

Review Articles