Bacteriological profile of neonatal and pediatrics sepsis in intensive care unit at a tertiary care hospital in western India
DOI:
https://doi.org/10.18203/2349-3291.ijcp20210521Keywords:
Neonatal sepsis, Bacteriological profile, Klebsiella pneumonia, Pediatrics sepsisAbstract
Background: Neonatal and pediatrics sepsis are one of the main causes of mortality in neonatal and pediatric intensive care units of developing countries. This study was conducted to determine bacteriological profile of neonatal and pediatrics sepsis in the intensive care unit.
Methods: A prospective cross-sectional study was conducted in the neonatal and pediatric intensive care unit, for the period of two years. All 400 neonates and pediatrics patients admitted with suspected clinical sepsis were included. Sepsis screens and cultures were sent under aseptic conditions. Isolation of microorganisms and their identification was done according to standard microbiological techniques bacteriological profile was analyzed with descriptive statistics.
Results: Incidence of septicemia is 35.34% in neonates, 9.83% in post neonates and 22.95% in older children. Most common associated factor in neonates were preterm 41.46% in neonates, fever of unknown origin 50% and 78.57% in post neonates and children respectively. Out of 232 suspected cases on neonates in 36.07% cases bacterial pathogen were isolated, 62 suspected cases on post neonates in 9.83% cases bacterial were isolated and 106 suspected cases of older children in 22.95% cases bacterial pathogen were isolated. Common bacterial species isolated were Klebsiella sp. 39.02% in neonates, S. aureus 50% and 35.71% in post neonates and older children respectively.
Conclusions: There is entail prevention of infection control measures and rational antibiotic strategy to decrease the economic burden of hospital and community.
Metrics
References
Kenneth CI, Olufmlayo YE, Iretiola BB. Bactriological profile of neonatal septicaemia in a tertiary hospital in Nigeria. Afri Health Sci. 2006;6(3):151-8.
Amela S, Fahrija S, Mustafa B, Zijad S. The Predictive score for early-onset neonatal sepsis. The Turkish J Pediatr. 2010;52:139-44.
Ghai OP, Paul VK, Bagga A. Essential pediatrics. CBS Publishers & Distributors Pvt Ltd. 2009;7:136-8.
Cecilia CM, Mary AC, Elizabeth EG, Jonathan GL, Joanne JL, Cecille YA. Etiology of neonatal sepsis in five urban hospitals in the Philippines. PIDSP J. 2011;12:75-85.
Rabia S, Nusrat K, Shugfta H. Bacteriology and Anti-Microbial Susceptibility of Neonatal Septicemia in NICU, PIMS, Islamabad- A Tertiary Care Hospital of Pakistan. Ann. Pak Inst Med Sci. 2010;6(4):191-5.
Santhanam S, Steele RW. Pediatric Sepsis. www.emedicine.medscape.com/article/972449- overview. Accessed on 09-06-2012.
Nwadioha SI, Nwokedi EO, Kashibu E, Odimayo MS, Okwori EE. A review of bacterial isolates in blood cultures of children with suspected septicaemia in a Nigerian tertiary Hospital. Afr J Microbiol Res. 2010;4(4):222-5.
Khan H, Khaliq N, Muhammad F. Pediatric Intencive Care Unit; Pattern of Admissions. Professional Med J. 2006;13(3):358-61.
Povoa P. C-reactive protein: a valuable marker of sepsis. Intensive Care Med. 2002;28:235-43.
Aletayeb SM, Khosravi AD, Dehdashtian M, Kompani F, Mortazavi SM, Aramesh RM. Identification of bacterial agents and antimicrobial susceptibility of neonatal sepsis: A 54-month study in a tertiary hospital. African J Microbiol Res. 2011;5(5)528-31.
Ahmad A, Hussain W, Lamichhane A, Muhammad A, Riaz L. Use of antibiotics in Neonatal sepsis at neonatal unit of a tertiary care hospital. Pak paed J. 2011;35(1):3-7.
Meremikwu MM, Nwachukwu CE, Asuquo AE, Okebe JU, Utsalo SJ. Bacterial isolates from blood cultures of children with suspected septicemia in calabar Nigeria. BMC infectious diseases. 2005;5:110-14.
Ahmed AN, Caowdhury MA, Hoque M, Darmstadt GL. Clinical and bacteriological profile of neonatal septicemia in a tertiary level pediatric hospital in Bangladesh. Indian pediatr. 2002;39:1034-39.
Jain NK, Jain VM, Maheshwari S. Clinical profile of Neonatal sepsis. Kathmandu university med j. 2003;1(2):117-20.
Kuruvilla KA, Pillai S, jesudason M, Jana AK. Bacterial profile of sepsis in a neonatal unit in south India. Indian paediatr. 1998;35:851-58.
Rizvi F, Afzal M, Khan A, Wahid S. Bacterial sensitivity in neonatal sepsis. J Islamabad med Dental college. 2007;5(2):153-60.
Rahman S, Hameed A, Roghani MT, Ullah Z. Multidrug resistant neonatal sepsis in Peshawar, Pakistan. Arch Dis Child Fetal Neonatal. 2002;87:52-4.
Chacko B, Sohi I. Early onset neonatal sepsis. Indian J paediatr. 2005;72(1):23-6.
Shaw CK, Shaw P, Thapalia A. Neonatal sepsis bacterial isolates and antibiotic susceptibility pattern at aNICu in a tertiary care hospital in western Nepal: A retrospective analysis Kathmandu University Med J. 2007;5(2):153-60.
Tsering D, Chanchal L, Pal R. Bacteriological profile of septicemia and risk factors in neonates and infants in Sikkim. J global infect disease. 2001;3(1):42-5.
Hasson SO, Naher HS, AIMrzoq JM. Gram positive bacteremia in febrile children under two years of age in Babylon province. Available at: www.uoba-bylon.edu.iq/uobcoleges/fleshare/articles/gram.pdf. Accessed on 20 June 2012.
Gwee A, Coghlan B, Evereti D, Chagoma N, Phiri A, Wilson L et al. Bacteremia in Malawian Neonates and young infants 2002-2007: A retrospective audit. BMJ Open. 2012;2(3).
Qureshi M, Aziz F. Prevalence of microbial isolates in blood cultures and their antimicrobial susceptibility profiles. Biomed. 2011;27:136-9.
Bhattaccharjee A, Sen MR, Prakash P, Gaur A, Anupurba S. Increased prevalence of Extended spectrum B lactamase producers in neonatal septicemic cases at a tertiary referral hospital. Indian J Med Microbiol. 2008;26(4):356-60.