Comparison between oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia
DOI:
https://doi.org/10.18203/2349-3291.ijcp20211079Keywords:
Anemia, Ferrous ascorbate, Colloidal ironAbstract
Background: Anemia is a global health issue. There is association of impaired cognition and iron deficiency anemia. Ferrous and ferric forms of oral iron preparations are available for the treatment of iron deficiency anemia. This study was conducted with an aim to compare the efficacy and safety of oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia.
Methods: It was a prospective interventional study with 12 weeks of treatment protocols alternatively assigned to children diagnosed with iron deficiency anemia. Patients received either of two iron preparation used in study and they were assessed at week 0, 4, 8 and 12.
Results: Hemoglobin (gm%) significantly increased from 7.40 to 12.87 in ferrous ascorbate group and from 7.24 to 11.32 in colloidal iron group at the end of 12 weeks of treatment (p<0.05). There was significant increase in corrected reticulocyte count (%) from 0.52 to 1.39 in ferrous ascorbate group and from 0.42 to 1.27 in colloidal iron group (p<0.05). Serum ferritin (mcg/liter) was also significantly increased from 11.54 to 21.53 in ferrous ascorbate group and from 10.57 to 20.52 in colloidal iron group at the end of 12 weeks (p<0.05).
Conclusions: The present study concluded that the ferrous ascorbate is an efficient oral iron supplement in the treatment of iron deficiency anemia in the pediatric age group compared to colloidal iron.
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References
Worldwide Prevalence of anemia.1993-2005. Retrieved from WHO Global Database on Anemia, Geneva. Available at https://www.who.int/vmnis/ anaemia/prevalence/summary/anaemia_data_status_t2/en/. Accessed on 10 December 2020.
Bharati S, Pal M, Bharati P. Prevalence of anemia among 6- to 59-month-old children in India: The latest picture through the NFHS-4. J Biosocial Sci. 2020;52(1):97-107.
Khedr E, Hamed SA, Elbeih E, Elshereef H, Ahmad Y, Ahmed S. Iron states and congnitive abilities in young adults: Neuropsychological and neurophysiological assessment. Eur Arch Psychiatry Clin Neurosci. 2008;258:489-96.
Bovell-Benjamin AC, Viteri FE, Allen LH. Iron absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status. Am J Clin Nutr. 2000;71(6):1563-9.
Lozoff B, Jimenez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med. 1991;325(10):687-94.
Kanchana, Ahuja S, Ngaraj N. Prevalence and risk factors of anemia in under five-year-old children's hospital. IJCP. 2018;5(2):499-502.
Saba F, Poornima S, Balaji PA, Varne SR, Jayashree K. Anemia among hospitalized children at a multispecialty hospital, Bangalore (Karnataka), India. J Family Med Prim Care. 2014;3(1):48-53.
Alvarez-Uria G, Naik PK, Midde M, Yalla PS, Pakam R. Prevalence and severity of anaemia stratified by age and gender in rural India. Anemia. 2014;2014:176182.
John JJ, Mohan G, Ajitha K, David A. Iron deficiency anemia among preschool children belonging to affluent families in Kerala, India. J Curr Res Sci Med. 2019;5:23-7.
Ganguly S, Dewan B, Philipose N, Samanta P, Paul D. Comparison between Ferrous Ascorbate and Colloidal Iron in the Treatment of Iron Deficiency Anemia in Children from Kolkata India. Bri J Med Med Res. 2012;2(2):195-205.
Shuchismita B, Gandham B. Magnitude of Anemia and Hematological Predictors among Children under 12 Years in Odisha, India. Anemia. 2016:10:2016.
Sahu T, Sahani N, Patnaim L. Chikdhood anemia - A study in tribal area of Mohana block in Orrisa. Indian J Comm Med. 2007;32(1):43-5.
Aedh A, Elfaki N, Souni E. Iron Deficiency Anemia and Associated Risk Factors among Teenagers in Najran, Saudi Arabia. IJMRHS. 2019;8(5):108-14.
Maiti D, Acharya S, Basu S. Recognizing missed opportunities to diagnose and treat iron deficiency anemia: A study based on prevalence of anemia among children in a teaching hospital. J Family Med Prim Care. 2019;8(3):899-903.
Yewale VN, Dewan B. Treatment of iron deficiency anemia in children: a comparative study of ferrous ascorbate and colloidal iron. Indian J Pediatr. 2013;80(5):385-90.
Patil P. Comparison of Therapeutic Efficacy of Ferrous Ascorbate and Iron Polymaltose Complex in Iron Deficiency Anemia in Children: A Randomized Controlled Trial. Indian J Pediatr. 2019;86(12):1112-7.
Panchal P, Desai M, Shah S, Solanki M. Evaluation of efficacy, safety and cost of oral andparentral iron preparation in patient with iron deficiency anemia. J appl Pharmac Sci. 2015;5(3):066-72.
Santen S, Mast Q, Oosting J, Ede A, Swinkle W et al. Hematologic parameters predicting a response to oral iron therapy in chronic inflammation. Hematol. 2014;99(9):171-3.
Azza M, Shata A, Kamal H, Ali O. A Comparative Study of Efficacy, Tolerability and Compliance of Oral Iron preparations for Iron Deficiency Anemia In Pregnant Women. Scienti Acad Pub. 2014;4(6):244-9.
Duque X, Martinez H, Vilchis-Gil J, Mendoza E, Flores-Hernández S, Morán S et al. Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial. Nutr J. 2014;13:71.
Panicker N, Hridya A, Prabhu R. Comparison of Efficacy and Safety Profile of Oral Iron Formulations in Patients with Iron Deficiency Anemia. Int J Pharm Sci Rev Res. 2016;41(2):248-52.
Cancelo-Hidalgo MJ, Castelo-Branco C, Palacios S, Haya-Palazuelos J, Ciria- Recasens M, Manasanch J et al. Tolerability of different oral iron supplements: a systematic review. Curr Med Res Opin. 2013;29(4):291-303.
Gupta N, Jahan U, Bais. Evaluation of efficacy and compliance of ferrous sulphate of national nutritional anemia prophylaxis and control programme in comparison with other iron preparations in antenatal females. Gynecology. 2019;9:5.
Geisser P, Müller A. Pharmacokinetics of iron salts and ferric hydroxide- carbohydrate complexes. Arzneimittelforschung. 1987;37(1):100-4.
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