Published: 2021-02-23

The circumcision blues: a case report with literature review

Meng Li, Kristen C. Lee, Thomas A. Nakagawa


An 11-day-old Caucasian male developed acquired methemoglobinemia as a result of repeated exposure to topical lidocaine/prilocaine cream following a circumcision. Our patient responded well with treatment of a single dose of intravenous (IV) methylene blue. Methemoglobinemia is a rare but well-explained complication of local anesthetics. It is important for providers to prescribe local anesthetics safely to avoid serious complications, especially with neonates who are at higher risk of developing methemoglobinemia.


Methemoglobinemia, Local anesthetics, Circumcision

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