Assessment of multisystem inflammatory syndrome in children related to COVID-19

Authors

  • Sayeeda Anwar Department of Pediatrics, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh
  • Zohora Jameela Khan Department of Pediatrics Hemato-oncology, DMCH, Dhaka, Bangladesh
  • Naznin Akhter Department of Pediatrics, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh
  • Fatema Farzana Department of Pediatrics, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh
  • Zannatul Shormin Department of Pediatrics, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh
  • Farzana Kabir Department of Pediatrics, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2349-3291.ijcp20213304

Keywords:

MIS-C, COVID-19, Pediatric population

Abstract

Background: The COVID-19 pandemic has caused devastating diseases worldwide both in children and adults. Subsequently, a serious and novel pediatric condition called children's multisystem inflammatory syndrome (MIS-C) has emerged and it is important to understand the temporal association between MIS-C and COVID-19. In hyper inflammation syndrome following COVID-19, MIS-C, and multi-organ involvement were documented in the pediatric population. The main goal of this study was to assess the relation of the MIS-C with COVID-19.

Methods: This single-center case-control study was conducted at Dhaka medical college hospital (DMCH), Dhaka, Bangladesh. Among 1715 studied population, 227 COVID-19 positive pediatric patients were included in this study. Among them 103 had features of MIS-C in the case group and 124 were in the control group without MIS-C.

Results: There were 6% MIS-C patients with COVID-19. The prevalence of male patients was observed in this study. The mean age of the patient group with MIS-C was 7.8±3.12 years. The frequencies of fever 93.3 vs 67.7%, p=0.045; conjunctivitis 75.6% vs 53.2%, p=0.039; rash 47.3% vs 16.1%; arterial hypotension 71.3 vs 12.9%, p=0.058 hypoxemia 80.4% vs 57.2%, p=0.049 and other features were significantly higher in MIS-C patients than the patients without MIS-C. More patients with MIS-C had cardiac abnormalities in our study.

Conclusions: MIS-C is an emerging clinical entity and this study was focused on the cases of MIS-C in the pediatric population withCOVID-19. In patients with atypical clinical findings and complaints about COVID-19, MIS-C-like illnesses should be considered.

Author Biography

Sayeeda Anwar, Department of Pediatrics, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh

Professor(Head),Department of Pediatrics, Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh

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Published

2021-08-23

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Original Research Articles