Incidence of congenital anomalies in newborns born to mothers with heart disease
DOI:
https://doi.org/10.18203/2349-3291.ijcp20210127Keywords:
Cardiac anomalies, Congenital anomalies, Congenital heart disease, Heart disease, Pregnancy outcomeAbstract
Background: Heart disease is seen in 1% pregnancies. Prior studies have either looked at only the prevalence of congenital heart diseases (CHD) in newborns or the congenital anomalies (CA) in babies born to those with chronic medical disorders as a whole. There is only sparse literature looking specifically at their prevalence in mothers with heart disease.
Methods: We aimed to study incidence of CAs in newborns born to mothers with heart disease and to study other relevant outcomes like prematurity, low birth weight and intrauterine growth retardation which have significant associations with CAs. The present study was a descriptive study consisting of retrospective and prospective data and consisted of pregnant women with heart disease from 2006 to 2010 and their newborns.
Results: 55 pregnant women with their 55 newborns were selected. Among the 55 newborns, 15% babies had congenital anomalies including CHD, 13% had only CHDs. 21% babies with CHDs were born to CHD mothers and none of the mother baby diagnosis was completely concordant. No statistically significant outcome of CA in newborns born to mothers with heart disease was found. No statistically significant associations among low birth weight, prematurity and CAs was found.
Conclusions: 15% had congenital anomalies including CHD. No statistically significant outcome of CA in newborns born to mothers with heart disease was found. Since the study population comprised of a small sample size, significant derivations could not be made. Further studies are required in this direction to see if associations are significant.
References
Ajao AE, Adeoye IA. Prevalence, risk factors and outcome of congenital anomalies among neonatal admissions in OGBOMOSO, Nigeria. BMC Pediatr. 2019;19(1):88.
WHO. WHO/Congenital anomalies. WHO 2016. Available at: http://www.who.int/mediacentre/factsheets/fs370/en/. Accessed on 6 October 2019.
Taksande A, Vilhekar K, Chaturvedhi P, Jain M. Congenital malformations at birth in Central India: A rural medical college hospital based data. Indian J Hum Genet. 2010;16(3):159-63.
Chaturvedi P, Banerjee KS. Spectrum of congenital malformations in the newborns from rural Maharashtra. Indian J Pediatr. 1989;56:501-7.
Bhat BV, Babu L. Congenital malformation at birth- a prospective study from South India. Indian J Pediatr. 1998;65(6):873-81.
DeSilva M, Munoz FM, Mcmillan M, Kawai AT, Marshall H, Macartney KK, et al. Congenital anomalies: case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2016;34(49):6015.
Indian Council of Medical Research, New Delhi. Reproductive health. Annual report 2002-03:91. Available at: http://icmr.nic.in/annual/hqds2003/English/ReproductiveHealth.pdf. Accessed on 6 October 2019.
Kalra A, Kalra K, Sharma V, Singh M, Dayal RS. Congenital malformations. Indian Pediatr. 1984;21(12):945-50.
Mathur BC, Kiran S, Devi KKV. Congenital malformations in newborns. Indian Pediatr. 1975;12:179-81.
Liu S, Rouleau J, León JA, Sauve R, Joseph KS, Ray JG, et al. Impact of pre-pregnancy diabetes mellitus on congenital anomalies, Canada, 2002-2012. Health Promot Chronic Dis Prev Can. 2015;35(5):79.
Bhatla N, Lal S, Behera G, Kriplani A, Mittal S, Agarwal N, et al. Cardiac disease in pregnancy. Int J Gynecol Obstet. 2003;82(2):153-9.
Abdel-Hady ES, El-Shamy M, El-Rifai AA, Goda H, Abdel-Samad A, Moussa S. Maternal and perinatal outcome of pregnancies complicated by cardiac disease. Int J Gynecol Obstet. 2005;90(1):21-5.
Shime J, Mocarski EJM, Hastings D, Webb GD, Mclaughlin PR. Congenital heart disease in pregnancy: short and long term implications. Am J Obstet Gynecol. 1987;156 (2):313-22.
Thilen U, Olsson SB. Pregnancy and heart disease: a review. Eur J Obstet Gynecol Reprod Biol. 1997;75(1):43-50
Siu SC, Sermer M, Colman JM, Alvarez AN, Mercier LA, Morton BC, et al. Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation. 2001;104(5):515-21.
Khairy P, Ouyang DW, Fernandes SM, Lee-Parritz A, Economy KE, Landzberg MJ. Pregnancy outcomes in women with congenital heart disease. Circulation. 2006;113(4):517-24.
Chou HH, Chiou MJ, Liang FW, Chen LH, Lu TH, Li CY. Association of maternal chronic disease with risk of congenital heart disease in offspring. Canadian Med Assoc J. 2016;188(17-18):E438-46.
Sunitha T, Prasoona KR, Kumari TM, Srinadh B, Deepika ML, Aruna R, et al. Risk factors for congenital anomalies in high risk pregnant women: A large study from South India. Egyptian J Med Hum Genet. 2017;18(1):79-85.
Chia Y, Yeoh S, Lim M, Viegas O, Ratnam S. Pregnancy outcome and mitral valve prolapse. Asia-Oceania J Obstet Gynaecol. 1994;20:383.
Yokouchi-Konishi T, Yoshimatsu J, Sawada M. Recurrent congenital heart diseases among neonates born to mothers with congenital heart diseases. Pediatr Cardiol. 2019;40:865.
Honein MA, Kirby RS, Meyer RE, Xing J, Skerrette NI, Yuskiv N, et al. The association between major birth defects and preterm birth. Matern Child Health J. 2009;13(2):164-75.
Wang X, Li P, Chen S, Xi L, Guo Y, Guo A, et al. Influence of genes and the environment in familial congenital heart defects. Mol Med Rep. 2014:1(2):695-700
Drenthen W, Boersma E, Balci A, Moons P, Roos-Hesselink JW, Mulder BJ, et al. Predictors of pregnancy complications in women with congenital heart disease. Eur Heart J. 2010;31(17):2124-32.
Bateman BT, Patorno E, Desai RJ, Seely EW, Mogun H, Dejene SZ, Fischer MA, et al. Angiotensin-converting enzyme inhibitors and the risk of congenital malformations. Obstet Gynecol. 2017;129:174-84.
Czeizel EA, Rockenbauer MA. Population-based case-control teratological study of furosemide treatment during pregnancy. Clin Drug Inv. 1999;18:307-15.
Duan L, Ng A, Chen W, Spencer HT, Nguyen J, Shen AY, et al. β-blocker exposure in pregnancy and risk of fetal cardiac anomalies. JAMA Intern Med. 2017;177(6):885-7.
