Prevalence of vitamin d deficiency and its correlation with anthropometric measurements in neonates in a tertiary care center: a cross sectional study
DOI:
https://doi.org/10.18203/2349-3291.ijcp20210116Keywords:
Vitamin D deficiency, Newborn, Cord blood, AnthropometryAbstract
Background: Globally hypovitaminosis D is highly prevalent among all population unsparing pregnant mothers. Maternal hypovitaminosis has negative implications on growing fetus. In India, only limited data is available on prevalence of neonatal vitamin D level. Hence this study was done to estimate the prevalence of cord blood vitamin D levels and its relation with anthropometric measurements in newborns.
Methods: A cross sectional study was conducted in a tertiary care center on 30 newborns. Cord blood 25 OHD levels and anthropometric measurements were taken. Data were analyzed statistically.
Results: Among 30 newborns, 10%, 43% and 46% of babies had vitamin D deficiency (<12 ng/ml), insufficiency and sufficiency respectively. 23% were low birth weight. 43% of low-birth-weight babies had statistically significant (p value<0.0001) hypovitaminosis D. No correlation found between vitamin D status and other anthropometric measurements.
Conclusions: Prevalence of hypovitaminosis D has negative implications on birth weight which needs further studies.
References
Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D Deficiency in Children and Its Management: Review of Current Knowledge and Recommendations. Pediatrics. 2008;122(2):398-417.
Kamboj P, Dwivedi S, Toteja GS. Prevalence of hypovitaminosis D in India & way forward. Indian J Med Res. 2018;148(5):548-56.
Kiely M, O’Donovan SM, Kenny LC, Hourihane JO, Irvine AD, Murray DM. Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland. J Steroid Biochem Mol Biol. 2017;167:162-8.
Kochar IS, Vij V, Sethi A. Prevalence of Vitamin D deficiency in cord blood. J Clin Neonatol. 2019;8(1):10.
World Health Organization, Food and Agriculture Organization of the United Nations, editors. Vitamin and mineral requirements in human nutrition. 2nd ed. Geneva: Rome: World Health Organization; FAO; 2004;341.
Wagner CL, Greer FR. American Academy of Pediatrics Section on Breastfeeding, American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122(5):1142-52.
Vitamin D Deficiency in Childhood-A Review of Current Guidelines on Diagnosis and Management. Available from: https://www.indianpediatrics.net/july2013/july-669-675.htm. Accessed on Sep 1, 2020.
Ariyawatkul K, Lersbuasin P. Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status. Eur J Pediatr. 2018;177(10):1541-5.
Khadilkar A, Khadilkar V, Chinnappa J, Rathi N, Khadgawat R, Balasubramanian S et al. Prevention and treatment of vitamin D and calcium deficiency in children and adolescents: Indian Academy of Pediatrics (IAP) guidelines. Indian Pediatr. 2017;54(7):567-73.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
Wierzejska R, Jarosz M, Klemińska-Nowak M, Tomaszewska M, Sawicki W, Bachanek M et al. Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth. Front Endocrinol. 2018;9:9.
Balasubramanian S, Dhanalakshmi K, Amperayani S. Vitamin D deficiency in childhood-A review of current guidelines on diagnosis and management. Indian Pediatr. 2013;50(7):669-75.
Cord Blood Vitamin D Levels of Term Neonates. Available from: https://www.indianpediatrics.net/jan2015/jan-75-76.htm. Accessed on Sep 10, 2020.
Thorne-Lyman A, Fawzi WW. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2012;26(1).
Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr. 2005;81(5):1060-4.
