DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20210113

Neonatal thyroid screening a tertiary care experience at VSS Medical College and Hospital, Burla

Vidhyadhara Naik T. L., Bineet Panigrahi, Sanjukta Panda

Abstract


Background: Congenital hypothyroidism is one of the most common preventable etiologies of mental retardation. The worldwide incidence of CH ranges from 1 in 3000 to 1 in 4000 live newborn. Objective of the study was to know the incidence of congenital hypothyroidism in this part of the country, which is necessary to understand the burden of congenital hypothyroidism to the society.

Methods: Primary serum TSH measurement in screening neonates with backup thyroxine (T4) determination in infants with high TSH levels (>20 mIU/l). TSH and FT4 were estimated by chemi luminescence immunoassay (CLIA) method using reagent monobind, INC.

Results: Serum TSH of screened neonates ranged between 0.16 mIU/l and 80.32 mIU/l, Mean±SD of sTSH being 5.80±3.96 mIU/l. Out of 2212 screened newborns, 9 newborns had sTSH value >20 mIU/l, who were recalled for confirmatory test, giving a recall rate of 0.4%. Out of 9 recalled newborns, 3 had persistently elevated sTSH >20 mIU/l making incidence of congenital hypothyroidism of 1:737 in our study.

Conclusions: We found a higher incidence of 1:737 neonatal hypothyroidism in this region as compared to estimated national incidence. CH being preventable cause of mental retardation and other harmful effects on a growing newborn, neonatal screening programme for congenital hypothyroidism is highly recommended.


Keywords


Congenital hypothyroidism, Neonatal thyroid screening, Primary serum TSH measurement, TSH levels

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References


Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 2010;5:17.

Bekhit OEM, Yousef RM. Permanent and Transient Congenital Hypothyroidism in Fayoum, Egypt: a descriptive retrospective study. PLoS One. 2013;8(6):e68048.

Agrawal P, Philip R, Saran S, Gutch M, Razi MS, Agroiya P, et al. Congenital hypothyroidism. Indian J Endo Meta. 2015;19:221-7.

Manglik AK, Chatterjee N, Ghosh G. Umbilical cord blood TSH levels in term neonates: a screening tool for congenital hypothyroidism. Indian Pediatr. 2005;42:1029-32.

Salerno M, Micillo M, Maio SD, Capalbo D, Ferri P, Lettiero T, et al. Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening. Eur J Endocrinol. 2001;145:377-83.

Zoeller RT, Rove J. Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J Neuroendocrinol. 2004;16:809-18.

Park SM, Chatterjee VK. Genetics of congenital hypothyroidism. J Med Genet. 2005;42(5):379-89.

Unüvar T, Demir K, Abacı A, Ataş A, Büyükgebiz A, Böber E. Monitoring and prognostic evaluation of patients with congenital hypothyroidism treated in a pediatric endocrinology unit. Turk J Pediatr. 2013;55(4):384-90.

Büyükgebiz A. Congenital hypothyroidism clinical aspects and late consequences. Pediatr Endocrinol Rev. 2003;1(2):185-90.

Anjum A, Afzal MF, Iqbal SM, Sultan MA, Hanif A. Congenital hypothyroidism in neonates. Indian J Endocrinol Metab. 2014;18(2):213-6.

Anastasovska V, Koviloska R, Kocova M. High incidence of congenital hypothyroidism in one region of the republic of Macedonia. Alkan J Med Genet. 2014;17(1):31-6.

Ammash IS, Aldoree F, Sulaiman TI, Al-Jumaily Ali, Mahmood WT. Pilot study on neonatal screening for congenital hypothyroidism in Iraq. J Fac Med Baghdad. 2008:50(4):416-9.

Ordooei M, Rabiei A, Soleimanizad R, Mirjalili F. Prevalence of permanent congenital hypothyroidism in children in Yazd, Central Iran. Iran J Public Health. 2013;42(9):1016-20.

Sanghvi U, Diwakar KK. Universal newborn screening for congenital hypothyroidism. Indian Pediatr. 2008;45(4):331-2.

Raj S, Baburaj S, George J, Abraham B, Singh S. Cord blood TSH level variations in newborn- experience from a rural centre in Southern India. J Clin Diagn Res. 2014;8(7):18-20.

Yousef RM, Kansouh MF, Hana MA, Bekhit OES. Indicators of the screening program of congenital hypothyroidism in fayoum governorate. 2013.

Sundararaman PG. Neonatal thyroid dysfunctionlessons from Indian experience. Thyroid Res Pract. 2013;10:7-8.