DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20205521

Clinical profile and aetiological factors of neonatal jaundice from a rural area of Kutch, Gujarat, India

Avinash Patel, Karan Saradava, Hasmukh Chauhan

Abstract


Background: Etiology of hyperbilirubinemia is not only crucial for optimal management of the patient but also it may have implications for subsequent pregnancies. The objective of this study was to study the clinical profile and the underlying aetiological factors leading to neonatal jaundice in this rural setting of Kutch District, Gujarat, India.

Methods: This prospective observational study was conducted in the neonatal intensive care unit (NICU) and Post Natal ward Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat. Total of 150 cases were enrolled for the study. Blood grouping and Rh typing of baby and mother were done. Cord blood bilirubin and haemoglobin, direct coomb's test (DCT) and bilirubin monitoring were done whenever there was a setting for Rh incompatibility.

Results: Among 150 neonates studied, majority had birth weight between 2501g and 3000g. Only 21 babies had birth weight <2.5kg (14%) (Table 2). Of the 150 neonates 85 were males and 65 were females.

Conclusions: This study concludes that physiological jaundice is the most common cause of neonatal jaundice in our hospital. This is followed by ABO incompatibility, sepsis, Rh incompatibility and idiopathic cases.


Keywords


ABO incompatibility etiology, Hyperbilirubinemia, Neonates

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References


Wong RJ, Bhutani VK. Pathogenesis and etiology of unconjugated hyperbilirubinemia in the newborn. UpToDate. Waltham, MA: UpToDate. 2015.

Kaplan M, Bromiker R, Schimmel MS, Algur N, Hmmerman C. Evaluation of discharge management in the prediction of hyperbilirubinemia: the Jerusalem experience. J Pediatr. 2007;150:412–7.

Maisel MJ, Kring F. Length of stay, jaundice and hospital stay. Pediatrics. 1998;10:995–8.

Escobar GJ, Greene JD, Hulac P, Kincannon E, Bischoff K, Gardner MN, et al. Rehospitalisation after birth hospitalisation: patients among infants of all gestations. Arch Dis Child. 2005;90:125–31.

Ip S, Chung M, Kulig J, O'Brien R, Sege R, Glicken S, et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics. 2004;114:e130–e153.

Narang A, Kumar P, Kumar R. Neonatal jaundice in very low birth weight babies. Indian J Pediatr. 2001;68:307–9.

Mishra S, Agarwal R, Deorari AK, Paul VK. Jaundice in the newborns. Indian J Pediatr. 2008;75:157–63.

Maisels MJ, Bhutani VK, Bogen D, Newman TB, Stark AR, Watchko JF. Hyperbilirubinemia in the newborn infants >35 weeks gestation: an update with clarifications. Pediatrics. 2009;124:1193–8.

Narang A, Gathwala G, Kumar P. Neonatal jaundice: an analysis of 551 cases. Indian Pediatr. 1997;34:429–32.

Najib KS, Saki F, Hemmati F, Inaloo S. Incidence, risk factors and causes of neonatal hyperbilirubinemia in the south of Iran (Fars Province). Iran Red Crescent Med J. 2013;15:260–3.

Sgro M, Campbell D, Shah V. Incidence and causes of severe neonatal hyperbilirubinemia in Canada. CMAJ. 2006;175:587–90.

Ipek IO, Bozayakut A. Clinically significant neonatal hyperbilirubinemia: an analysis of 546 cases in Istanbul. J Trop Pediatr. 2008;54:212-3.

Olusanya BO, Osibanjo FB, Slusher TM. Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and Meta-analysis. PLoS One. 2015;10.

Bhutani VK. Evidence based issues regarding neonatal hyperbilirubinemia. Paediatrics Review. 2005;114:130-53.

Singhal PK, Singh M, Paul VK, Deorari AK, Ghorpade MG. Spectrum of neonatal hyperbilirubinemia: An analysis of 454 cases. Indian Pediatr. 1992;29:319-25.

Effiong CE. Neonatal jaundice in Ibadan. Incidence and etiologic factors born in hospital, Nigeria. J National Medical Associa. 1975;67(3):208-10.

Stoll BJ, Kliegman RM. Jaundice and hyperbilirubinemia in the newborn. Nelson textbook of pediatrics. 19th ed. Philadelphia: WB Saunders, 2011:562-569.

Bahl L, Sharma R, Sharma J.Aetiology of neonatal jaundice at Shimla. Ind Paediatr. 1994;31:1275-8.

Sgro M, Campbell D, Shah V. Incidence and causes of severe neonatal hyperbilirubinemia in Canada. CMAJ. 2006;175:587–90.

Ali A, Altunhan H, Konak M, Koc H, Ors R. Role of subgroup incompatibility in newborn jaundice requiring exchange transfusion. Eur J Gen Med. 2014;11:66–70.

American Academy of Pediatrics Subcommittee on hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Clinical practice guideline. Pediatrics. 2004;114(1):296–316.

Kaplan M, Hammermann C, Vreman HJ, Wong RJ, Stevenson DK. Hemolysis and hyperbilirubinemia in ABO heterospecific neonates. J Pediatr. 2010;157:772–7.

Kaplan M, Wong RJ, Sibley E, Stevenson DK, Neonatal jaundice and liver disease. 9th ed. Martin RJ, Fanaroff AA, Walsh MC, eds. Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. vol 2. St. Louis: Elsevier Mosby; 2011:1443.

Maisels MJ, Kring E. Risk of sepsis in newborns with severe hyperbilirubinemia. Pediatrics. 1992;90:741–3.

Merchant RH, Merchant SM, Babar ST. A study of 75 cases of neonatal jaundice. Indian Pediatr. 1975;12:889-93.

Manorama V, Chatwal J, Singh D. Neonatal hyperbilirubinemia, Indian J Paediatr. 1988;55:899-904.

Bajpai PC, Mishra PK, Agarwal M. An aetiological study of neonatal hyperbilirbinemia. Indian J Pediatr. 1971;38:424-9.