DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20160180

A rare case of congenital leukemia: acute myeloblastic leukemia in a neonate with Down syndrome

Fatima Shirly Anitha G., Danny Darlington C

Abstract


Congenital leukemia is an exceedingly uncommon disease in newborn and is usually diagnosed at birth or within one month of life. It is usually associated with a fatal outcome. Neonates with Down syndrome have an increased risk of congenital leukemia. Because of the rapid doubling time of leukemic cells, the disease becomes clinically evident at birth or shortly thereafter. We report a case of congenital leukemia in a newborn with Down syndrome, the diagnosis of which was established with strong clinical suspicion and confirmed with haematological investigations.


Keywords


Congenital leukemia, Down syndrome

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References


Aier M, Zadeng T, Basu D, Biswal N. Congenital leukemia in Down’s syndrome: A case report. Indian J Pathol Microbiol. 2002;45(3):355-7.

Prashad HVR, Kumar GN. Congenital leukemia in a two month old boy. Internet J Pediat Neonatol. 2007;6(2):1-2.

Iselius WS, Jacobs P, Morton N. Leukemia & Transient leukemia in Down’s syndrome. Human Genetics. 1990;85:477-85.

Chessells J. Blood disorders in children with Down’s syndrome: Overview and update. Forum on Learning Disability and The Down’s Syndrome Medical Interest Group, Royal Society of Medicine: 2001 April 26; London. UK: Oxford PharmaGenesis™ Ltd; 2002. Choi JK. Hematopoietic Disorders in Down Syndrome. Int J Clin Exp Pathol. 2008;1:387-95.

Badhe PB, Sane SY. Congenital leukemia – Organ involvement in six autopsy cases. J Postgrad Med. 1992;38:127.

Klusmann J, Creutzig U, Zimmermann M, Dworzak M, Jorch N, Langebrake C, et al. Treatment and prognostic impact of transient leukemiain neonates with Down syndrome. J Am Soc Hematol. 2008;111:2991-8.