Clinicoetiological profile of infantile onset seizure disorder at a tertiary care hospital

Poojitha Kanuparthi, Sahana Kaup Sathish Rao, Prakash R. M. Saldanha


Background: Current study was conducted with the objective to identify the type of seizures in infants and to know the underlying etiological factors and to know the presence of co-morbidities.

Methods: Hospital based retrospective study of 35 children conducted from January 2018 to January 2020. Files of children who were diagnosed with infantile onset seizures during that period were retrieved and analyzed.

Results: Out of the 35 children with seizures, generalized tonic clonic seizures was the commonest type of seizures 20 (57%), followed by simple partial and myoclonic seizures in 20% and 11.4% respectively. Structural causes were the commonest identifiable cause of seizures. Developmental delay was the most common co-morbidity followed by visual impairment.

Conclusions: Seizures in children less than 2 years is a potentially preventable entity, likely to be amenable to better perinatal care, early identification and management of seizures. Commonly associated co-morbidity with seizures was developmental delay that requires close followup and early intervention.


Infantile onset seizure, EEG, Neuroimaging, Outcome

Full Text:



Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and seizures in Rochester, Minnesota, 1935-1984. Epilepsia. 1993;34:453-6.

Wilmshurst JM, Gaillard WD, Vinayan KP, Tsuchida TN, Plouin P, Van Bogaert P, et al. Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics. Epilepsia. 2015;56(8):1185-97.

Eltze CM, Chong WK, Cox T, Whitney A, Cortina-Borja M, Chin RF, et al. A population-based study of newly diagnosed epilepsy in infants. Epilepsia. 2013;54(3):437-45.

Altunbaşak S, Incecik F, Hergüner O, Refik BH. Prognosis of patients with seizures occurring in the first 2 years. J Child Neurol. 2007;22:307-13.

Battaglia D, Randò T, Deodato F, Bruccini G, Baglio G, Frisone MF, et al. Epileptic disorders with onset in the first year of life: neurological and cognitive outcome. Eur J Paediatr Neurol. 1999;3(3):95-103.

Matsumoto A, Watanabe K, Sugiura M, Negoro T, Takaesu E, Iwase K. Etiologic factors and long-term prognosis of convulsive disorders in the first year of life. Neuropediatrics. 1983;14:231-4.

Kharod P, Mishra D, Juneja M. Drug-resistant epilepsy in Indian children at a tertiary-care public hospital. Childs Nerv Syst. 2019;35(5):775-8.

Jauhari P, Boggula R, Bhave A, Bhargava R, Singh C, Kohli N, et al. Aetiology of intellectual disability in paediatric outpatients in Northern India. Dev Med Child Neurol. 2011;53(2):167-72.

Adhikari S, Sathian B, Koirala DP, Rao KS. Profile of children admitted with seizures in a tertiary care hospital of western Nepal. BMC Pediatr. 2013;13:43.

Ernestina EM, Shahnawaz A, Panpan F, Dongchi Z. Profile and clinical characterization of seizures in hospitalized children. Pan Afr Med J. 2016;24:313.

Idro R, Gwer S, Kahindi M, Gatakaa H, Kazungu T, Ndiritu M, et al. The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital. BMC Pediatr. 2008;8:5.

Saravanan S. Profile of children admitted with seizures in a tertiary care hospital in South India. IOSR J Dent Med Sci. 2013;11:56-61.

Hsieh DT, Walker JM, Pearl PL. Infantile seizures: Infants are not just little children. Curr Neurol Neurosci Rep. 2008;8:139-44.

Poudel P, Parakh P, Mehta K. Clinical profile, aetiology and outcome of afebrile seizures in children. JNMA J Nepal Med Assoc. 2013;52:260-6.