DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20205526

Hereditary spastic paraplegia-a differential for spastic paraplegia in children

Niharika Shetty, Sahana Devadas, Mallesh Kariappa

Abstract


Hereditary spastic paraplegia (HSP) is a group of neurodegenerative disorders with familial origin mainly affecting the lower limbs. It has a prevalence of 3-10/100,000. The diagnosis is by symptomatology, clinical examination and neuroimaging to rule out other causes of spastic paraplegia. The diagnosis is confirmed by genetic analysis. Since this disorder is slowly progressive with nonspecific MRI brain findings the diagnosis can be delayed with delay in the start of rehabilitation measures. This disorder is usually diagnosed in the adult life and the literature has very few cases of paediatric HSP and hence we are reporting a case of HSP. Here we present the case of two siblings who presented to us with progressive weakness of both the lower limbs.


Keywords


Hereditary spastic paraplegia, Paediatrics, Neurodegenerative disorder

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References


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