Van Wyk Grumbach syndrome: a case report

Ravi Bhatia, Gunjan Bhatia


Van Wyk Grumbach Syndrome is characterized by long standing hypothyroidism, precocious puberty, Ovarian cysts and delayed bona age. We present a case of a 12 year old female who presented with Short stature and precocious puberty.  The Patient responded well to L- thyroxine therapy.


Van Wyk Grumbach syndrome, Hypothyroidism, Precocious puberty

Full Text:



Styne DM, Grumbach MM. William's textbook of Endocrinology. 11th ed . Philadelphia: Saunders (Elsevier); 2008. Puberty: Ontogeny, neuroendocrinology, physiology and disorders. 969–1166.

Van Wyk JJ, Grumbach MM. Syndrome of Precocious menstruation and galactorrhea in juvenile hypothyroidism. An example of hormonal overlap in pituitary feedback. J Pediatr. 1960;57: 416-35.

Gordon CM, Austin DJ, Radovic S, Lufer MR. Primary hypothyroidism presenting as severe vaginal bleeding in a pre pubertal girl. J Peditar Adolesc Gynecol. 1997;10:35-8.

Rastogi A, Bhadada S, Bhansali A. An unusual presentation of a usual disorder: Van Wyk Grumbach Syndrome. Indian J endocrinol Metab. 2011;15(suppl 2):141-3.

Baranowski E, Hogler W. An unusual presentation of acquired hypothyroidism: the van wyk grumbach syndrome. Eur J Endocrinol. 2012;166(3):537-42.

Sneha LM, Thanasegarapandian K, Paramasivam V, Scott J. Short Stature an interesting association. Indian J Hum Genet. 2013;19(1):101-3.

Bhattacharya M, Mitra AK. Regressive of precocious puberty in a child with hypothyroidism after thyroxine therapy. Indian Pediatr. 1992;29:96-8.