Vitamin D levels in children with bronchial asthma
DOI:
https://doi.org/10.18203/2349-3291.ijcp20204537Keywords:
Vitamin D deficiency, Bronchial asthma, Chronic inflammatory disorderAbstract
Background: Bronchial asthma is a common chronic inflammatory disorder of the airways in childhood. Vitamin D, initially described as a vitamin that regulated calcium homeostasis, has also been shown to exert important antimicrobial effects and is also a potent immune system regulator having a potential role in various allergic diseases. The main objective of this study was to look the levels of vitamin D in children with bronchial asthma and to study the co relationship between vitamin D levels and severity of asthma.
Methods: This study included 80 (40 asthmatic children and 40 healthy controls) children aged between 4 and 15 year. Serum vitamin D levels where determined and compared between the two groups. The association between vitamin D levels and severity of asthma was studied in the asthmatic children.
Results: Among 40 asthmatic children the mean serum vitamin D level was 16.6±11.56 ng/ml, while as the mean vitamin D levels in healthy control subjects was 24.225±2.764 ng/ml and the difference between the two groups was statistically significant (p=0.001). Vitamin D deficiency was highly prevalent in asthmatic patients and there was a direct and a significant relationship between serum vitamin D levels and severity of asthma.
Conclusion: In this study, vitamin D levels were considerably lower in children with asthma than in healthy children. Also, in this study vitamin D deficient asthma patients have more severe asthma than the patients who have sufficient vitamin D levels.
References
From the Global strategy for asthma Management and prevention. Global initiative for Asthma (GINA) 2020. Available at: http://www.ginasthma.org/. Accessed on 20 August 2020.
Vander Werff SD, Diaz JR, Reyneveld R, Heymans MW, Campos PM, Bonet GM et al. Prediction of asthma by common risk factors: a follow up study in Cuban school children. J Investig Allergol Clin Immunol. 2013;23(6):415-20.
Holt PG, Strickland DH. Interactions between innate and adaptive immunity in asthma pathogenesis: new perspective from studies on acute exacerbations. J Allergy Clin Immunol. 2010;125:963-72.
Black PN, Sragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest. 2005;128(6):3729-8.
Camargo CA Jr, Rifas-Shiman SL, Litonjua AA, Rich-Edwards JW, Weiss ST, Gold DR et al. Maternal intake of vitamin D pregnancy and risk of recurrent wheeze in children at 4 years of age. Am J Clin Nutri. 2007;85(3):788-95.
Bhrem JM, Celedon JC, Scoto-Quiros ME, Avila L, Hunninghake GM, Forno E et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respiratory Crit Care Med. 2009;179(9):765-71.
Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management program study. J Allergy Clin Immunol. 2010;126(1):52-85.
Mawer EB, Hayes ME, Heys SE, Davies M, White A, Stewart MF. Constitutive synthesis of 1,25-dihydroxyvitamin D3 by a human small cell lung cancer cell line. J Clin Endocrinol Metabol. 1994;82(1):118-22.
Schwartz GG, Whitlatch LW, Chen TC, Lokeshwar BL, Hollick MF. Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Cancer Epidemiol Biomarkers Prev. 1998;7(5):391-5.
Cross HS, Bareis P, Hofer H, Bischof MG, Bajna E, Kriwanek S et al. 25 Hydroxyvitamin D3,1 alpha hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids. 2001;66(3-5):287-92.
Hewison M, Burke F, Evans KN, Lammas DA, Sansom DM, Liu P et al. Extrarenal 25 hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Molecular Biol. 2007;103(3-5):316-21.
Sandhu MS, Casale TB. The role of vitamin D in asthma. Am J Allergy Asthma Immunol. 2010;105:191-9.
Datta S, Pal M, Malik SK. Blood Vitamin D concentration in adult asthmatic patients. J Drug Deliv Therap. 2014;4(2)36-8.
Kolokotroni O, Papadopoulou A, Middelton N, Kouta C, Nicolaidou VR et al. Vitamin D Levels and status amongst asthmatic and non asthmatic adolescents in Cyprus. BMC Public Health. 2015;15:48.
Omashker AR, Prithvi AB, Vanitha MN. Gowda et al. Vitamin D and its role in bronchial Asthma. J Clin Diagn Res. 2014;8(10):PC4-7.
Chinellato L, Piazza M, Sandri M, Peroni DG, Cardinale F, Piacentini GL et al. Serum vitamin D levels and exercise induced bronchoconstriction in children with asthma. Eur Respir J. 2011;37:1366-70.
Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DYM. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med. 2010;181:699-704.
Shebl RE, Shehata SM, Elgabry M, Ali SAI, Elsaid HH. Vitamin D and phenotypes of bronchial asthma. Egy J Chest Dis Tuberculosis. 2013;62(2):201-5.
Szefler S, Weiss S, Tonascia A, Adkinson NF, Bender BG, Cherniack R et al. The Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Eng J Med. 2000;343(15):1054-63.