Clinical profile of children with epilepsy: a cross-sectional study
Keywords:Epilepsy, Cerebral palsy, Seizures, Sodium valproate
Introduction: One of the most common chronic neurological disorders is epilepsy, affecting as many as 45 million individuals worldwide. The occurrence is higher in children below the age of three. Around 60 percent to 70 percent of epilepsy patients have an effective response to treatment with antiepileptic medications. This cross-sectional study aimed to explore the clinical profile of children with epilepsy.
Methods: Total of 100 children with different types of epilepsy was included in this study. After getting informed consent from the parents, all the demographic data, family history, clinical and laboratory investigations were recorded, and the results were statistically analyzed and discussed.
Results: 69 patients had tonic-clonic seizures, 15 patients had a complete partial seizure, 7 patients had absence seizures, 4 patients had unclassified seizures, 3 patients had simple partial seizures, 1 patient had myoclonic seizures, atonic seizures and multiple seizures. Aetiology, 72 patients had an idiopathic cause, 10 patients had hypoxic ischemia, 8 patients had Central nervous system (CNS) infection, 4 patients had cerebral palsy and space-occupying lesion, 2 patients had trauma. Comorbidity, 84 patients had none, 4 patients had mental retardation, 3 patients had eye diseases, cerebral palsy, protein-energy malnutrition, mental retardation with cerebral palsy, 1 patient had a hearing impairment. Drug therapy, 63 patients had sodium valproate, 11 patients had carbamazepine, 2 patients had multidrug treatment, and 1 patient had sodium phenytoin.
Conclusion: A significant amount of the aetiology of the condition is expressed among preventable causes of epilepsy. For generalized tonic clonic seizure, sodium valproate was observed to have more positive effects in paediatric patients.
Bell GS, Neligan A, Sander JW. An unknown quantity - the worldwide prevalence of epilepsy. Epilepsia. 2014;55(7):958-62.
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55:475-82.
Berg AT, Berkovic SF, Brodie MJ. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51:676685.
Thurman DJ, Beghi E, Begley CE. Standards for epidemiologic studies and surveillance of epilepsy. Epilepsia. 2011;52(7):22.
Mac TL, Tran DS, Quet F, Odermatt P, Preux PM, Tan CT. Epidemiology, aetiology, and clinical management of epilepsy in Asia: a systematic review. Lancet Neurol. 2007;6:533-43.
Masri A, Badran E, Hamamy H, Assaf A, Al-Qudah AA. Etiologies, outcomes, and risk factors for epilepsy in infants: a case-control study. Clin Neurol Neurosurgeon. 2008;110:352-6.
Aicardi J. Syndromic classification in the management of childhood epilepsy. J Child. Neurol. 1994;9(2):S11-4.
Liou HH, Oon PC, Lin HC, Wang PJ, Chen TH. Risk factors associated with infantile spasms: a hospital-based case-control study in Taiwan. Epilepsy Res. 2001;47(1-2):91-8.
Sridhar K, Kumar P, katariya S. Post asphyxial encephalopathy in preterm neonates. Indian J Paediatr. 2001;68(12):1121-5.
Miller SP, J. Weiss BS, Barnwell A, Ferriero DM, Latal-Hajnal B. Seizures associated with brain injury in newborns with perinatal asphyxia. Neurology. 2002;58:542-8.
Gunn AJ, Gunn TR. Changes in risk factors for hypoxic-ischemic seizures in term infants. Aust N Z J Obstetric Gynaecol. 1997;37(1):36-9.
Baheti R, Gupta BD, Baheti R. A Study of CT and EEG findings in Patients with Generalized or Partial Seizures in Western Rajasthan. JIACM. 2003;4(1):25-9.
Szurhaj W, Derambure P. The role of the EEG in epilepsy management. Rev Neurol. 2004;160(11):1113-9.
Russ SA, Larson K, Halfon N. A National Profile of Childhood Epilepsy and Seizure Disorder. Paediatrics. 2012;129:256-64.
Kolk A. Neurocognitive development of children with congenital unilateral brain lesion and epilepsy. Brain & Development. 2001;23(2):88-96.
Shorvon SD, Farmer PG. Epilepsy in developing countries: a review of epidemiological, socio-cultural, and treatment aspects. Epilepsia. 1988;29:(3):6-54.
Bassili A, Omar T, Zaki A, Fattah M. Pattern of diagnostic and therapeutic care of childhood epilepsy in Alexandria, Egypt. Int J Quality Health Care. 2002;14;277-84.