Published: 2021-10-25

A study of the outcome of acute encephalitis syndrome in children

Suhani Barbhuiyan, Gayatri Bezboruah


Background: Acute encephalitis syndrome (AES) is defined as a person of any age, at any time of the year, with acute onset of fever and a change in mental status (including symptoms such as confusion, disorientation, coma, inability to talk) and/or new onset of seizures (excluding simple febrile seizures) [WHO]. Japanese encephalitis (JE) is one of the leading causes of AES affecting children and adolescents in the tropical countries. Objective of the study were to study the outcome of children with AES. The study was conducted in the department of pediatrics, Gauhati medical college and hospital, Guwahati from 1st July 2016 to 30th June 2017.

Methods: Patients admitted in the pediatrics department of Gauhati medical college and hospital, Guwahati with diagnosis of AES during the study period were taken into account based on inclusion and exclusion criteria.

Results: It has been observed that age, awareness among caregivers, poor GCS, multiple seizures, shock are important factors in the outcome of AES.

Conclusions: From the present study, prognosis of the cases may be predicted and measures taken to improve outcome


AES, JE, Outcome

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Saminathan M, Karuppanasamy K, Pavulraj S, Gopalakrishnan A, Rai RB. AES: a complex zoonotic disease. Int J Livest Res. 2013;3(2):174-7.

Kumar R, Mathur A, Kumar A. Japanese encephalitis-an important cause of acute childhood encephalopathy in Lucknow, India. Postgrad Med J. 1988;64:18-22.

Verma A, Ahmed Z, Shekhar S, Ahsan M. Spectrum Analysis of Cases of Japanese Encephalitis in Jharkhand, India. J Dental Med Sci. 2017;16(3):16-9.

Yashodhara P, Madhavi N. Clinical Profile and Outcome of Viral Encephalitis in Pediatric Department in Government General Hospital, Guntur. Int J Sci Res. 2015;11(4):2141-6.

Kakoti G, Dutta P, Das BR, Bora J, Mahanta J. Clinical Profile and Outcome of Japanese Encephalitis in Children admitted with Acute Encephalitis Syndrome. Biomed Res Int. 2013;1-5.

Khinchi YR, Kumar A, Yadav S. Study of acute encephalitic syndrome in children. J College Med Sci Nepal. 2010;6:7-13.

Sambasivam E, Muthaiyan J, Mohan S, Ayyavoo AM, Jayachandran G. Clinical profile and predictors of outcome in children admitted to PICU with acute encephalitis syndrome. Int J Contemporary Pediatr. 2017;4(4):1214-7.

Karmarkar SA, Aneja S, Khare S, Saini A, Seth A, Chauhan BK. A study of acute febrile encephalopathy with special reference to viral etiology. Indian J Pediatr. 2008;75:801-5.

Rayamajhi A, Ansari I, Ledger E. Clinical and prognostic features among children with acute encephalitis syndrome in Nepal; a retrospective study. BMC Infectious Dis. 2011;11:294.

Gogoi A, Panyang R, Baro L. Acute encephalitis syndrome in children with special reference to Japanese encephalitis: a retrospective analysis. J Evolution Med Dent Sci. 2016;5(51):3289-94.

Luo D, Song J, Ying H, Yao R, Wang Z. Prognostic factors of early sequelae and fatal outcome of Japanese encephalitis. Southeast Asian J Trop Med Public Health 1995 Dec;26(4):694-8.

Burke DS, Lorsomrudee W, Leake CJ, Hoke CH, Nisalak A, Chongswasdi V, Laorakpongse T. Fatal outcome in Japanese encephalitis. Am J Trop Med Hyg. 1985;34(6):1203-10.

Baruah HC, Biswas D, Patgiri, Mahanta J. Clinical Outcome and Neurological Sequelae in Serologically Confirmed Cases of Japanese Encephalitis Patients in Assam, India. Indian Pediatric. 2002;39:1143-8.

De S, Samanta S, Halder S, Sarkar P. Clinical profile and outcome of children admitted with Acute Encephalitic Syndrome in a Tertiary Care hospital in West Bengal, India. J Dental Med Sci. 2015;14(11):8-12.