Predictors of mortality in neonatal septicemia in a tertiary care centre


  • Dhara Gosai Department of Paediatrics, B. J. Medical College, Ahmedabad, Gujarat, India
  • Bela H. Shah Department of Paediatrics, B. J. Medical College, Ahmedabad, Gujarat, India
  • Jyothi S. Department of Paediatrics, B. J. Medical College, Ahmedabad, Gujarat, India



Morbidity, Neonatal mortality, Septicemia


Background: Neonatal septicemia continues to be a major cause of mortality and morbidity in new-borns all over the world. Aim and objectives of the study were determining the risk factors for mortality in neonatal septicemia.

Methods: A retrospective observational study of the demographics, clinical features and laboratory parameters of 100 neonates admitted in NICU of a tertiary care hospital from September 2019 to March 2020.

Results: 67% of neonates delivered outside centre and 33% of neonates delivered at centre were found to have sepsis exclusively based on culture positivity. A significant association was found between very low birth rate (VLBW) (p value<0.001), prematurity (p value<0.01) and high neonatal mortality. Among the different clinical presentations of neonatal sepsis, lethargy (p value<0.02), apnea (p value<0.01) and hypothermia (p value<0.02) were found to be frequently associated with neonatal mortality. Further, C-reactive protein (CRP) positivity (p value<0.003), hyperglycaemia (p value<0.0009) and thrombocytopenia (p value<0.0009) were also associated with high neonatal mortality. Gram positive bacteria were frequently isolated from blood cultures of deceased neonates, Coagulase negative staphylococci (CoNS) (36.1%), being the commonest bacteria followed by B. subtilis (11.1%), Klebsiella spp. (11.1%) and Acinetobacter spp. (8.3%).

Conclusion: Demographic factors like VLBW, prematurity, outborn deliveries, clinical and laboratory parameters like lethargy, apnea, hypothermia, thrombocytopenia and hyperglycemia are strong predictors of mortality in neonatal.

Author Biography

Jyothi S., Department of Paediatrics, B. J. Medical College, Ahmedabad, Gujarat, India



Neonatal mortality-UNICEF DATA. Available from: Accessed on 25 July 2020.

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Original Research Articles