Fungal endocarditis in neonate

Authors

  • Manoj Kumar Verma Department of Pediatrics, Maulana Azad Medical College, Delhi, India
  • Abnish Kumar Bharti Department of Pediatrics, Hindu Rao Hospital & North DMC Medical College, Delhi, India
  • Rahul Jaiswal Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Uttar Pradesh, India
  • Amit Gupta Department of Paediatrics, Motilal Nehru Medical College, Uttar Pradesh, India
  • Anuj Gupta Department of Pediatrics, Hindu Rao Hospital & North DMC Medical College, Delhi, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20203656

Keywords:

Neonatal endocarditis, Fungal endocarditis, Infective endocarditis

Abstract

Neonatal endocarditis is a rare but usually fatal disease. Fungal endocarditis is an uncommon complication of invasive fungal infections and is associated with a high burden of morbidity and mortality. It frequently occurs in premature infants. The majority of these infections are caused by Candida (60-70%) and Aspergillus species (20-25%). The diagnosis is difficult because the criteria that have suggested and used in adults are not readily applicable for neonates. The incidence of fungal endocarditis in a neonate is on the rise, reported in the last decade secondary to use of central venous lines, frequent use of broad-spectrum antibiotics and neonatal surgical interventions. 

Author Biographies

Manoj Kumar Verma, Department of Pediatrics, Maulana Azad Medical College, Delhi, India

Senior Resident, Maulana Azad Medical College Delhi

Abnish Kumar Bharti, Department of Pediatrics, Hindu Rao Hospital & North DMC Medical College, Delhi, India

Senior Resident, Department of Pediatrics, Hindu Rao Hospital & North DMC Medical College, Delhi, India

Rahul Jaiswal, Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Uttar Pradesh, India

Senior Resident,  Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences. Lucknow U.P. India.

Amit Gupta, Department of Paediatrics, Motilal Nehru Medical College, Uttar Pradesh, India

Senior Resident, Department of Pediatrics, Motilal Nehru Medical college Prayagraj U.P. India

Anuj Gupta, Department of Pediatrics, Hindu Rao Hospital & North DMC Medical College, Delhi, India

Senior Resident,  Department of Paediatrics, Hindu Rao Hospital & North DMC Medical College,   Delhi, India.

 

References

Daher AH. Infective endocarditis in neonates. Clinical Pediatrics. 1995;4:198-206.

Mayayo E, Moralejo J, Camps J, Guarro J. Fungal endocarditis in premature infants. Clinical infectious Diseases. 1996;22:366-8.

Fleming RE, Barenkamp SJ, Jureidini SB. Successful treatment of a Staphylococcal endocarditis vegetation with tissue plasminogen activator. J. Pediatr. 1998;132:535-7.

Ferrieri P, Gewitz MH, Gerber MA, Newburger JW, Dajani AS, Shulman ST, et al. Committee on rheumatic fever, endocarditis, and kawasaki disease of the American heart association council on cardiovascular disease in the young. unique features of infective endocarditis in childhood. Circulation. 2002;105:2115-26.

Tissieres P, Jaeggi ET, Beghetti M, Gervaix A. Increase of fungal endocarditis in children. Infection.2005;33:267-72.

Millard DD, Shulman ST. The changing spectrum of neonatal endocarditis. Clin Perinatol. 1988;15:587-607.

Sharma J, Nagraj A. Fungal endocarditis in a premature infant complicated by right atrial mycetoma and inferior venaca thrombosis images. Pediatr Cardiol. 2009;11(4):6-11.

O’Callaghan C, McDougall P. Infective endocarditis in neonates. Arch Dis Child. 1988;63:53-7.

Pana DZ, Dotis J, Losifidis E, Roilides E. Fungal endocarditis in neonates: a review of seventy-one cases(1971-2013). The Infectious Disease Journal. 2015;34(8):803-8.

Wiley JM, Seibel NL, Walsh TJ. Efficacy and safety of amphotericin B lipid complex in 548 children and adolescents with invasive fungal infections. Pediatr Infect Dis J. 2005;24:167-74.

Cuna CD, Rizzo V, Malaigia L, Biasini A. Successful medical treatment of Candida albicans endocarditis in an extremely low birth weight infant. J Clin Neonatol. 2017;6:94-6.

Downloads

Published

2020-08-25

Issue

Section

Case Reports