Serum albumin and total protein level as plausible marker for diagnosis of protein energy malnutrition in children under age 5 years
DOI:
https://doi.org/10.18203/2349-3291.ijcp20203171Keywords:
Albumin, Protein energy malnutrition, Serum level, Total proteinAbstract
Background: The circulating concentration of transport protein, traditionally albumin, has been used to define protein deficiency. However, few studies have been conducted to see if there is any correlation between serum total protein and albumin levels in children with PEM. Hence the study was planned to estimate serum total protein, serum albumin levels in children with PEM and healthy controls.
Methods: All the children were divided in two groups. Case Group A consist of 250 children with protein energy malnutrition and control Group B consist of healthy 250 children. Venous blood of amount 3 ml was collected with full aseptic precautions. The blood was collected in the EDTA vacutainer and test tube. Serum total protein was estimated by Biuret method, serum albumin was estimated by Bromocresol green dye method (BCG dye).
Results: When the mean serum levels of albumin levels and the total protein levels were measured in the controls as well as case groups, there was decrease in levels in case group as compared to control group. This difference of decrease when evaluated statistically it was found to be statistically significant. When the albumin/globulin ratio was calculated in both the groups, it was found to be statistically lower in case group as compared to control group. PEM children have low serum total protein and albumin levels as compared to healthy controls (p<0.001), this is probably due to decreased intake of proteins and reduced biosynthesis. PEM children have lower hemoglobin levels as compared to healthy controls; this is probably due to deficiency of iron and other micronutrients, which is often found in a child with malnutrition.
Conclusions: Early diagnosis and prompt management of PEM and its complications can prevent development of permanent physical and mental retardation.
References
Grover Z, Ee LC. Protein energy malnutrition. Pediatric Clin. 2009;56:1055-68.
Pollitt E. Functional significance of the covariance between protein energy malnutrition and iron deficiency anemia. The J Nutrit. 1995;125:2272S-7S.
Namasivayam AM, Steele CM. Malnutrition and dysphagia in long-term care: a systematic review. J Nutrit Gerontol Geriatr. 2015;34:1-21.
Collins S, Dent N, Binns P, Bahwere P, Sadler K, Hallam A. Management of severe acute malnutrition in children. The Lancet. 2006;368:1992-2000.
Neumann C, Harris DM, Rogers LM. Contribution of animal source foods in improving diet quality and function in children in the developing world. Nutr. Res. 2002;22:193-220.
Schaible UE, Stefan H. Malnutrition and infection: complex mechanisms and global impacts. PLoS Med. 2007:4.
Batool R, Butt MS, Sultan MT, Saeed F, Naz R. Protein-energy malnutrition: a risk factor for various ailments. Crit Rev Food Sci Nutrit. 2015;55:242-53.
Shetty P. Malnutrition and undernutrition. Med. 2003;31:18-22.
Spiekeman AM. Nutritional assessment (protein nutriture). Analy Chem. 1995;67:429-36.
Souza MC, Martins VL, Almeida LF, Neto ODP, Gaião EN, Araujo MCU. Kinetics independent spectrometric analysis using non-linear calibration modelling and exploitation of concentration gradients generated by a flow-batch system for albumin and total protein determination in blood serum. Talanta. 2010;82:1027-32.
Sampath G, Parikh S, Sangram P, Briggs D. Rabies post-exposure prophylaxis in malnourished children exposed to suspect rabid animals. Vaccine. 2005;23:1102-5.
Asha K, Anil G, Mital G, Parin S, Vikas V, Oza R. Influence of protein energy malnutrition on level of serum zinc in children. Int J Res Med. 2016;5:14-6.
Turkay S, Kus S, Gokalp A, Baskin E, Onal A. Effects of protein energy malnutrition on circulating thyroid hormones. Indian Pediatr. 1995;32:193.
Adegbusi H, Sule M. Anthropometric and biochemical assessment among under five children in Kusada Local Government Area, Katsina State, Nigeria. Bayero J Pure Applied Sci. 2011;4:137-40.
Mishra S, Bastola S, Jha B. Biochemical nutritional indicators in children with protein energy malnutrition attending Kanti Children Hospital, Kathmandu, Nepal. Kathmandu University Med J. 2009;7:129-34.
