A clinical study of spectrum of low platelet count to establish etiology, diagnosis, complications and prognosis in newborns admitted in Al-Ameen medical college hospital NICU, Bijapur, Karnataka, India

Authors

  • Rizwan U. Zama Department of Pediatrics, Al Ameen Medical College, Bijapur, Karnataka, India
  • Naushad Ali N. Malagi Department of Pediatrics, Al Ameen Medical College, Bijapur, Karnataka, India
  • A. N. Thobbi Department of Pediatrics, Al Ameen Medical College, Bijapur, Karnataka, India
  • Salim A. Dhundasi Department of Physiology, Al Ameen Medical College, Bijapur, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3291.ijcp20202569

Keywords:

Birth asphyxia, Low platelet count, Mucosal bleeding, Neurodevelopment, Septicemia

Abstract

Background: In the newborn low platelet count is a common finding in both preterm and term newborn. It has been estimated that as many as 22% of all new borns admitted to NICU develop low platelet counts. A platelet count of less than 150,000/mL is defined as thrombocytopenia irrespective of the age of the individual.

Methods: All the neonates underwent necessary blood investigations like Complete blood counts, (including platelet counts, HB estimation, Red cell indices and PCV), Capsular Polysaccharide - reactive protein. (CRP), Peripheral Smear study, Blood culture, BT, CT, PT, aPPT, Anti-platelet Antibodies.

Results: The prevalence of thrombocytopenia in our study was 28%. The proportion of severe thrombocytopenia among the neonatal thrombocytopenia, 11.2% in our study.

Conclusions: It can be concluded that thrombocytopenia is very much common in among our NICU admissions. Septicemia is its most important and most common cause.

References

Roberts I, Murray NA. Neonatal thrombocytopenia: new insights into pathogenesis and implications for clinical management. Curr Opin Pediatr. 2001;13(1):16-21.

Sola MC, Del Vecchio A, Rimsza LM. Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. Clin Perinatol. 2000;27(3):655-79.

Merchant R, Irani A, Desai M, Mehta BC, Rodrigues R. Neonatal thrombocytopenia. Indian J Pediatr. 1981;48(393):447-3.

Merchant RH. Neonatal thrombocytopenia. Indian J Med Sci. 1989;43(5):132-5.

Raizada N, Lal A. Bhatia RC, Jain BK, Chander K, Goyal A. Neonatal thrombocytopenia due to pregnancy induced hypertension. Indian J Pediatr. 1996;63(2):226-8.

Israels SJ, Rand ML, Michelson AD. Neonatal platelet function. Semin Thromb Hemost 2003;29(4):363-72.

Nathan DG, Orkin Stuart H, A Thomas Look. Nathan and Oski's Hematology of infancy and childhood. 6th ed. Philadelphia: Saunders; 2003.

Murray NA, Roberts IA. Circulating megakaryocytes and their progenitors in early thrombocytopenia in preterm neonates. Pediatr Res. 1996;40(1):112-9.

Wasiluk A. Thrombocytopoiesis in healthy term newborns. J Perinat Med. 2005;33(3):252-4.

Dame C. Developmental biology of thrombopoietin in the human fetus and neonate. Acta Paediatr Suppl. 2002;91(438):54-65.

Dame C. Thrombopoietin in thrombocytopenias of childhood. Semin Thromb Hemost. 2001;27(3): 215-28.

Castle V, Andrew M, Kelton J, Giron D, Johnston M, Carter C. Frequency and mechanism of neonatal thrombocytopenia. J Pediatr. 1986;108(5):749-55.

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Published

2020-06-24

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Original Research Articles