C-reactive protein levels in children with uncomplicated malaria
DOI:
https://doi.org/10.18203/2349-3291.ijcp20170712Keywords:
C-reactive rotein, Uncomplicated malariaAbstract
Background: Malaria is one of the biggest burden in terms of morbidity and mortality among all infectious diseases and continues to be a major health problem in India. The objective of this study was to study the levels of C-reactive protein in children with uncomplicated Malaria. To correlate C-reactive protein levels with malaria parasite density and species of Malaria.
Methods: Retrospective study was done in Father Muller Medical College, Mangalore, Karnataka. 50 patients below 15 years of age malaria parasite positive by fluorescent test (MPFT) and by Peripheral smear formed the subjects and CRP levels and parasite densities was noted down into the proforma.
Results: The age group predominantly was children more than 10 years. Plasmodium vivax was the type of malaria in 60% children. Most common symptoms were fever (100%), chills and rigors (41%), vomiting (48%) and headache (24%). Clinical signs observed were hepatomegaly (30%) and splenomegaly (64%). Mean levels of C reactive protein (CRP) were 42.91%with standard deviation of 31.62. Mean CRP levels were high in children with Falciparum malaria (44.51±34.19).58% had CRP levels ranging from 6-50 mg/l. 50% children with CRP levels >50 mg/L had parasite density of (++++) which is 100 parasites per 1 field of quantitative buffy coat.
Conclusions: C-reactive protein levels are markedly elevated in acute malarial infection in paediatric age group.It correlates well with disease severity.
Metrics
References
Park K. Malaria. In: preventive and social medicine. 22th Edition. Publishers: Banarsidas Bhanot Publishers: Jabalpur; 2013:232-245.
WHO: World Malaria Report. Geneva, Switzerland: World Health Organization; 2015. Available at http://apps.who.int/iris/bitstream/10665/200018/1/9789241565158_eng.pdf. Accessed on 6 August 2016.
National vector borne disease control programme. Director General Health Services. Ministry of Health and Family Welfare. Malaria, 2016; http://nvbdcp.gov.in/. Accessed on 10 December 2016.
Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340:448.
Agrawal V, Jain V, Biswas S. Evaluation of C-reactive protein as a biochemical marker for assessing disease severity in Malaria. J Dent Med Sci. 2013;8(2):23-6.
Ansar W, Bandyopadhyay SM, Chowdhury S, Habib SH, Mandal C. Role of C-reactive protein in complement-mediated hemolysis in malaria. Glycoconj J. 2006;23:233-40.
History, pathogenesis, clinicalfeatures, diagnosis, treatment, complications and control of malaria. Available at: http://www.malariasite.com. Accessed on 14 December 2016.
Guidelines for the treatment of Malaria.3rd edition. Geneva: World health Organization; 2015. Available at http://www.ncbi.nlm.nih.gov/books/. Accessed on 1 March 2016.
Pinto MJ, Rodrigues SR, Desouza R, Verenkar MP. Usefulness of quantitative buffy coat blood parasite detection system in diagnosis of malaria. Indian J Med Microbiol. 2001;19:219-21.
Chatriwala M. Prognostic value of serum C-reactive protien In malaria. Int J Biomed and Adv Res. 2014;5(10):513.
Hurt N, Smith T, Teuscher T, Tanner M. Do high levels of C-reactive protein in Tanzanian children indicate malaria morbidity. Clin Diagn Lab Immunol. 1994;1(4):437-44.
Paul R, Sinha PK, Bhattacharya R, Banerjee AK, Raychaudhuri P, Mondal J. Study of C - reactive protein as a prognostic marker in malaria from Eastern India. Adv Biomed Res. 2012;1:41.
Naik P, Voller A. Serum C reactive protein levels and falciparum malaria. Trans Roy Trop Med. 1994;78:812-3.
Félix Y, Hugues A, David K, Adou Y, Brice B, Dagui M et al. Assessment of inflammatory and immunity proteins during falciparum malaria infection in children of Côte d’Ivoire. Am J Sci Ind Res. 2010;1(2):2.
Downloads
Published
How to Cite
Issue
Section
