Chronic intestinal pseudo-obstruction in newborn: a case report

Mahmoud M. Osman; Ahmed Hassan Sherif; Mohammed Saleh Alissa; Suzan Abdel Hamid; Adel Abdelsalam Alatar

doi:10.18203/2349-3291.ijcp20202161

Authors

Mahmoud M. Osman Department of Pediatrics, Neonatal intensive care unit (NICU), Alyammamah Hospital, Riyadh, KSA
Ahmed Hassan Sherif Department of Pediatrics, Neonatal intensive care unit (NICU), Alyammamah Hospital, Riyadh, KSA
Mohammed Saleh Alissa Department of Pediatrics, Neonatal intensive care unit (NICU), Alyammamah Hospital, Riyadh, KSA
Suzan Abdel Hamid Department of Pediatrics, Neonatal intensive care unit (NICU), Alyammamah Hospital, Riyadh, KSA
Adel Abdelsalam Alatar Department of Pediatrics, Neonatal intensive care unit (NICU), Alyammamah Hospital, Riyadh, KSA

DOI:

https://doi.org/10.18203/2349-3291.ijcp20202161

Keywords:

Impaired peristalsis, Intestinal obstruction, Motility disorder, Pseudo-obstruction

Abstract

Chronic intestinal pseudo-obstruction (CIPO) is a rare and serious disorder of the gastrointestinal tract motility with the primary defect of impaired peristalsis. Symptoms are consistent with a bowel obstruction, although mechanical obstruction cannot be identified. It is a rare differential diagnosis for neonatal intestinal obstruction. Herein we report a case of neonate with non-resolving intestinal pseudo-obstruction, presenting since birth as progressive abdominal distention. The diagnosis was made by exclusion of mechanical causes of intestinal obstruction via thorough imaging studies.

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References

Gabbard L, Lacy E. Chronic intestinal pseudo-obstruction. Nutr Clin Pract. 2013;28:307-16.

Amiot A, Cazals-Hatem D, Joly F, Lavergne-Slove A, Peuchmaur M, Bouhnik Y, et al. The role of immunohistochemistry in idiopathic chronic intestinal pseudoobstruction (CIPO): a case-control study. Am J Surg Pathol. 2009 May 1;33(5):749-58.

Wangler MF, Gonzaga-Jauregui C, Gambin T. Heterozygous denovo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome. PLoS Genet. 2014;10:e1004258.

Di Nardo G, Karunaratne B, Frediani S, De Giorgio R. Chronic intestinal pseudo-obstruction: Progress in management? Neurogastroenterol Motility. 2017;29:e13231.

Di Nardo G, Di Lorenzo C, Lauro A, Stanghellini V, Thapar N, Karunaratne TB, et al. Chronic intestinal pseudo‐obstruction in children and adults: diagnosis and therapeutic options. Neurogastroenterol Motility. 2017 Jan;29(1):e12945.

Politei J, Durand C, Schenone A, Torres A, Mukdsi J, Thurberg L. Chronic intestinal pseudo-obstruction. Did you search for lysosomal storage diseases? Molec Genet Metab Reports. 2017;(11):8-11.

Ambartsumyan L, Rodriguez L. Gastrointestinal motility disorders in children. Gastroenterol Hepatol. 2014;10(1):16-26.

Choudhury A, Rahyead A, Kammermeier J, Mutalib M. The use of pyridostigmine in a child with chronic intestinal pseudo-obstruction. Pediatrics. 2018 Apr 1;141(Supplement 5):S404-7.

Muto M, Matsufuji H, Tomomasa T, Nakajima A, Kawahara H, Ida S, et al. Pediatric chronic intestinal pseudo-obstruction is a rare, serious, and intractable disease: a report of a nationwide survey in Japan. J Pediatr Surg. 2014;49(12):1799-803.

De Giorgio R, Cogliandro RF, Barbara G, Corinaldesi R, Stanghellini V. Chronic intestinal pseudo-obstruction:clinical features, diagnosis,and therapy. Gastroenterol Clin North Am. 2011; 40:787-807.

Khoa T, Gerson J. Other dysmotilities including chronic intestinal pseudo-obstruction syndrome. In Walker’s Pediatric Gastrointestinal Disease. 6th Edition. Kleinman RE, Goulet OJ editors. North Carolina: People’s Medical Publishing House; 2018: 2671-2692.

De Araújo P, Wefford V, Simão D. Pseudo-pediatric chronic intestinal obstruction - A literature review. Residência Pediátrica. 2019;9(2):138-47.