The usefulness of neutrophil to lymphocyte ratio in febrile seizure


  • Pooja A. Department of Paediatric, AJ Institute of medical science, Mangalore, Karnataka, India
  • Amitha Rao Aroor Department of Paediatric, AJ Institute of medical science, Mangalore, Karnataka, India
  • Santosh T. Soans Department of Paediatric, AJ Institute of medical science, Mangalore, Karnataka, India



Complex Febrile Seizures, Intracranial infection, Neutrophil-to-Lymphocyte Ratio, Simple Febrile Seizures, Tertiary care hospital


Background: Febrile seizure is an event in infancy or childhood, usually occurring between 3 months and 5 years of age associated with fever but without evidence of intracranial infection. The aim of the study was to estimate the usefulness of neutrophil-to-lymphocyte ratio (NLR) in patients with simple and complex febrile seizures.

Methods: Retrospective case control   study was done in a paediatric in patients admitted to tertiary care hospital.  Study period   was from January 2017 to December 2019. 200 children were analysed in the study. 100 out of 200 were under control group (febrile children without seizure). Remaining 100 were under case group (children with febrile seizure), 54 out of 100 children had   complex febrile seizure, 46 out of 100 had simple febrile seizure. NLR ratio was done in all children.

Results: Total 200 children were analysed in this study.   High NLR ratio   was noted among the cases (87 out of 100) compared to control (30 out of 100) p value = <0.001. Among the cases CFS had high NLR ratio compared to SFS, however p value was not significant (0.072).

Conclusions: Children with febrile seizure had high NLR ratio compared to those without seizures. However no significant difference was noted between those with simple febrile seizure and complex febrile seizure   However, larger trials are required   to assess whether higher NLR can be taken as an independent risk factor for febrile seizure.


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Original Research Articles