Role of clinical laboratory parameters in management of dengue infection, beyond infancy: a tertiary care experience

Nijaguna Nanjundappa, Basavaraja Gangasamudra Veerappa, Keshavamurthy Mysore Lakshmikantha, Prerana S. Nesargi


Background: Dengue infection is the most rapidly spreading mosquito-borne viral disease in the world affecting millions of children all over the world with varied clinical features. This study was done to study the clinical profile of children in a tertiary teaching hospital

Methods: This is a prospective observational study, all children with features suggestive of dengue infection as per WHO 2012 guidelines were enrolled in the study. Their demographic data was collected and after through clinical examination and initial stabilization they we categorized and treated accordingly.

Results: A total of 92 children were enrolled, males were 56.5% and females 45.6%, and most of the children were from Bangalore and neighbouring state Andhra Pradesh. Fever constituted the major compliant while pain abdomen with vomiting was the major warning sign. Thrombocytopenia was seen in 95.6%. Majority required IV fluids (69.5%) whole ventilation was required in 8.6%.the overall mortality was 8.6%.

Conclusions: Dengue fever is a dynamic disease with heterogeneous manifestation. The treatment many range from simple IV fluids to Ventilator support. Good clinical monitoring will identify those children developing shock and institute early treatment.


Dengue fever, Children, Management

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Dengue-treatment, prevention and control. WHO, 2009.

Gibbons RV, Vaughn DW, 2002. Dengue: an escalating problem. BMJ. 2002;324:1563-6.

Halstead SB, Lan NT, Myint TT, Shwe TN, Nisalak A, Kalyanarooj S, et al. Dengue hemorrhagic fever in infants: Research opportunities ignored. Emerg Infect Dis. 2002;8:1474-9.

Mandal S, Ganguly J, Sil K, Chatterjee S, Chatterjee K, Sarkar P. Clinical profiles of dengue fever in a teaching hospital of eastern india: national journal of medical research. 2013;3(2).

Handbook for clinical management of dengue. WHO, 2012.

Seema A, Singh V, Kumar S, Kumar A, Dutta S. The Changing Clinical Spectrum of Dengue Fever in the 2009 Epidemic in North India: A Tertiary Teaching Hospital Based Study. Journal of Clinical and Diagnostic Research. 2012;6(6):999-1002.

Tripathy BK, Gupta B, Sinha RS, Prasad S, Sharma DK. Experience in adult population in dengue outbreak in Delhi. J Assoc Physicians India. 1998;46(3):273-6.

Mittal H, Faridi MM, Arora SK, Patil R. Clinicohematological profile and platelet trends in children with dengue during 2010 epidemic in north India. Indian J Pediatr. 2012;79(4):467-71.

Khan AH, Hayat AS, Masood N, Solangi NM, Shaikh TZ. Frequency and Clinical Presentation of Dengue Fever at Tertiary Care Hospital of Hyderabad/Jamshoro. 2010;9(2):88-94.